methyl (1R,3R,4R,5S)-3-(tert-butyldimethylsilyloxy)-4-hydroxy-5-methylcyclohexane-1-carboxylate

Base Information

Chemical Name:methyl (1R,3R,4R,5S)-3-(tert-butyldimethylsilyloxy)-4-hydroxy-5-methylcyclohexane-1-carboxylate
CAS No.:1026073-45-9
Molecular Formula:C₁₅H₃₀O₄Si
Molecular Weight:302.486
Hs Code.:

Synonyms:methyl (1R,3R,4R,5S)-3-(tert-butyldimethylsilyloxy)-4-hydroxy-5-methylcyclohexane-1-carboxylate

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Chemical Property of methyl (1R,3R,4R,5S)-3-(tert-butyldimethylsilyloxy)-4-hydroxy-5-methylcyclohexane-1-carboxylate

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Technology Process of methyl (1R,3R,4R,5S)-3-(tert-butyldimethylsilyloxy)-4-hydroxy-5-methylcyclohexane-1-carboxylate

There total 15 articles about methyl (1R,3R,4R,5S)-3-(tert-butyldimethylsilyloxy)-4-hydroxy-5-methylcyclohexane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1026073-44-8
methyl (1R,3R,4R,5R)-3,4-epoxy-5-(tert-butyldimethylsilyloxy)cyclohexane-1-carboxylate

: 917-54-4
methyllithium

: 1026073-45-9
methyl (1R,3R,4R,5S)-3-(tert-butyldimethylsilyloxy)-4-hydroxy-5-methylcyclohexane-1-carboxylate

Guidance literature:: methyllithium; With copper(I) cyanide; In tetrahydrofuran; diethyl ether; at -78 - 10 ℃; for 0.5h;

With boron trifluoride diethyl etherate; In tetrahydrofuran; diethyl ether; at -78 ℃; for 0.333333h;

methyl (1R,3R,4R,5R)-3,4-epoxy-5-(tert-butyldimethylsilyloxy)cyclohexane-1-carboxylate; With methanol; triethylamine; more than 3 stages;

Reference yield: 78.0%

: 917-54-4
methyllithium

: 1026073-45-9
methyl (1R,3R,4R,5S)-3-(tert-butyldimethylsilyloxy)-4-hydroxy-5-methylcyclohexane-1-carboxylate

Guidance literature:: methyllithium; With boron trifluoride diethyl etherate; copper(I) cyanide; In tetrahydrofuran; diethyl ether; at -78 - -10 ℃; for 5.83333h;

With ammonia; ammonium chloride; In tetrahydrofuran; diethyl ether; water;

Reference yield:

: 1026073-44-8
methyl (1R,3R,4R,5R)-3,4-epoxy-5-(tert-butyldimethylsilyloxy)cyclohexane-1-carboxylate

: 1026073-45-9
methyl (1R,3R,4R,5S)-3-(tert-butyldimethylsilyloxy)-4-hydroxy-5-methylcyclohexane-1-carboxylate

Guidance literature:: methyl (1R,3R,4R,5R)-3,4-epoxy-5-(tert-butyldimethylsilyloxy)cyclohexane-1-carboxylate; With boron trifluoride diethyl etherate; methyllithium; copper(l) cyanide; In tetrahydrofuran; diethyl ether; at -78 ℃;

With triethylamine; In tetrahydrofuran; methanol; diethyl ether;