1-(6-O-acetyl-2,3,4-tri-O-benzyl-α-D-mannopyranosyl)-2-o-(p-toluenesulfoamidyl)phenylethyne

Base Information

Chemical Name:1-(6-O-acetyl-2,3,4-tri-O-benzyl-α-D-mannopyranosyl)-2-o-(p-toluenesulfoamidyl)phenylethyne
CAS No.:220339-89-9
Molecular Formula:C₄₄H₄₃NO₈S
Molecular Weight:745.893
Hs Code.:

Synonyms:1-(6-O-acetyl-2,3,4-tri-O-benzyl-α-D-mannopyranosyl)-2-o-(p-toluenesulfoamidyl)phenylethyne

Suppliers and Price of 1-(6-O-acetyl-2,3,4-tri-O-benzyl-α-D-mannopyranosyl)-2-o-(p-toluenesulfoamidyl)phenylethyne

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-(6-O-acetyl-2,3,4-tri-O-benzyl-α-D-mannopyranosyl)-2-o-(p-toluenesulfoamidyl)phenylethyne

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-(6-O-acetyl-2,3,4-tri-O-benzyl-α-D-mannopyranosyl)-2-o-(p-toluenesulfoamidyl)phenylethyne

There total 3 articles about 1-(6-O-acetyl-2,3,4-tri-O-benzyl-α-D-mannopyranosyl)-2-o-(p-toluenesulfoamidyl)phenylethyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 61613-20-5
N-tosyl-2-iodoaniline

: 220339-86-6
8-O-acetyl-3,7-anhydro-4,5,6-tri-O-benzyl-1,2-dideoxy-D-glycero-D-talo-oct-1-ynitol

: 220339-89-9
1-(6-O-acetyl-2,3,4-tri-O-benzyl-α-D-mannopyranosyl)-2-o-(p-toluenesulfoamidyl)phenylethyne

Guidance literature:: With copper(l) iodide; N-butylamine; triphenylphosphine; palladium diacetate; In tetrahydrofuran;

Reference yield:

: 65556-30-1
1,6-di-O-acetyl-2,3,4-tri-O-benzyl-α-D-mannopyranoside

: 220339-89-9
1-(6-O-acetyl-2,3,4-tri-O-benzyl-α-D-mannopyranosyl)-2-o-(p-toluenesulfoamidyl)phenylethyne

Guidance literature:: Multi-step reaction with 3 steps

1: TMSOTf / CH₂Cl₂ / 15 h / 20 °C

2: 2.32 g / aq. n-Bu₄NF / tetrahydrofuran / 1.5 h / 20 °C

3: 96 percent / Ph₃P; CuI; n-BuNH₂ / Pd₂[dba]3*CHCl₃ / tetrahydrofuran / 3 h / 20 °C

With copper(l) iodide; trimethylsilyl trifluoromethanesulfonate; tetrabutyl ammonium fluoride; N-butylamine; triphenylphosphine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; dichloromethane; 3: Sonogashira coupling;
DOI:10.1039/b414905j

Reference yield:

: Acetic acid (2R,3R,4R,5R,6R)-3,4,5-tris-benzyloxy-6-trimethylsilanylethynyl-tetrahydro-pyran-2-ylmethyl ester

: 220339-89-9
1-(6-O-acetyl-2,3,4-tri-O-benzyl-α-D-mannopyranosyl)-2-o-(p-toluenesulfoamidyl)phenylethyne

Guidance literature:: Multi-step reaction with 2 steps

1: 2.32 g / aq. n-Bu₄NF / tetrahydrofuran / 1.5 h / 20 °C

2: 96 percent / Ph₃P; CuI; n-BuNH₂ / Pd₂[dba]3*CHCl₃ / tetrahydrofuran / 3 h / 20 °C

With copper(l) iodide; tetrabutyl ammonium fluoride; N-butylamine; triphenylphosphine; tris(dibenzylideneacetone)dipalladium⁽⁰⁾ chloroform complex; In tetrahydrofuran; 2: Sonogashira coupling;
DOI:10.1039/b414905j