N,N-ditetradecyl-N^α-t-butoxycarbonyl-N^im-tosyl-L-histidinamide

Base Information

• Chemical Name: N,N-ditetradecyl-N^α-t-butoxycarbonyl-N^im-tosyl-L-histidinamide
• CAS No.: 83824-97-9
• Molecular Formula: C₄₆H₈₀N₄O₅S
• Molecular Weight: 801.231
• Mol file: 83824-97-9.mol

Synonyms:N,N-ditetradecyl-N^α-t-butoxycarbonyl-N^im-tosyl-L-histidinamide

Chemical Property of N,N-ditetradecyl-N^α-t-butoxycarbonyl-N^im-tosyl-L-histidinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N-ditetradecyl-N^α-t-butoxycarbonyl-N^im-tosyl-L-histidinamide

There total 1 articles about N,N-ditetradecyl-N^α-t-butoxycarbonyl-N^im-tosyl-L-histidinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

ditetradecylamine (17361-44-3) + Nα-t-butoxycarbonyl-Nim-tosyl-L-histidine dicyclohexylamine adduct (65057-34-3,210694-29-4) → N,N-ditetradecyl-Nα-t-butoxycarbonyl-Nim-tosyl-L-histidinamide (83824-97-9)

Guidance literature:

With toluene-4-sulfonic acid; dicyclohexyl-carbodiimide; In dichloromethane; a) 0 deg C, 3 h, b) RT, 12 h;

DOI:10.1246/bcsj.55.3004

Reference yield:

N,N-ditetradecyl-Nα-t-butoxycarbonyl-Nim-tosyl-L-histidinamide (83824-97-9) → (S)-2-Amino-N,N-ditetradecyl-3-[1-(toluene-4-sulfonyl)-1H-imidazol-4-yl]-propionamide (83824-99-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 1.5h; Ambient temperature;

DOI:10.1246/bcsj.55.3004

Reference yield:

N,N-ditetradecyl-Nα-t-butoxycarbonyl-Nim-tosyl-L-histidinamide (83824-97-9) → N,N-ditetradecyl-Nα-(6-bromohexanoyl)-L-histidinamide (83824-98-0)

Guidance literature:

Multi-step reaction with 2 steps

1: CF₃COOH / CH₂Cl₂ / 1.5 h / Ambient temperature

2: 93 percent / Et₃N / CH₂Cl₂ / 2.5 h / 0 °C

With triethylamine; trifluoroacetic acid; In dichloromethane;

DOI:10.1246/bcsj.55.3004

upstream raw materials:

ditetradecylamine

N^α-t-butoxycarbonyl-N^im-tosyl-L-histidine dicyclohexylamine adduct

Downstream raw materials:

(S)-2-Amino-N,N-ditetradecyl-3-[1-(toluene-4-sulfonyl)-1H-imidazol-4-yl]-propionamide

N,N-ditetradecyl-N^α-(6-bromohexanoyl)-L-histidinamide