10-deacetoxy-10-[2-(o-nitrophenylselenyl)ethyl]-7-O-triethylsilylbaccatin III

Base Information

• Chemical Name: 10-deacetoxy-10-[2-(o-nitrophenylselenyl)ethyl]-7-O-triethylsilylbaccatin III
• CAS No.: 325735-50-0
• Molecular Formula: C₄₄H₅₉NO₁₁SeSi
• Molecular Weight: 884.998
• Mol file: 325735-50-0.mol

Synonyms:10-deacetoxy-10-[2-(o-nitrophenylselenyl)ethyl]-7-O-triethylsilylbaccatin III

Chemical Property of 10-deacetoxy-10-[2-(o-nitrophenylselenyl)ethyl]-7-O-triethylsilylbaccatin III

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 10-deacetoxy-10-[2-(o-nitrophenylselenyl)ethyl]-7-O-triethylsilylbaccatin III

There total 1 articles about 10-deacetoxy-10-[2-(o-nitrophenylselenyl)ethyl]-7-O-triethylsilylbaccatin III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

ortho-nitrophenyl selenocyanate (51694-22-5) + 10-deacetoxy-10-hydroxypropyl-7-O-triethylsilylbaccatin III (204764-74-9) → 10-deacetoxy-10-[2-(o-nitrophenylselenyl)ethyl]-7-O-triethylsilylbaccatin III (325735-50-0)

Guidance literature:

With tributylphosphine; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.3987/COM-00-9051

Reference yield: 81.0%

10-deacetoxy-10-[2-(o-nitrophenylselenyl)ethyl]-7-O-triethylsilylbaccatin III (325735-50-0) → 10-allyl-10-deacetoxy-7-O-triethylsilylbaccatin III (208407-16-3)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; at 20 ℃; for 3h;

DOI:10.3987/COM-00-9051

Reference yield:

10-deacetoxy-10-[2-(o-nitrophenylselenyl)ethyl]-7-O-triethylsilylbaccatin III (325735-50-0) → C61H92N2O13Si2

Guidance literature:

Multi-step reaction with 4 steps

1.1: 81 percent / m-CPBA / tetrahydrofuran / 3 h / 20 °C

2.1: 91 percent / NaH (60 percent oil suspension) / tetrahydrofuran / 2 h / 0 °C

3.1: OsO₄; NMO / tetrahydrofuran; H₂O / 2 h / 20 °C

3.2: 84 percent / NaIO₄ / tetrahydrofuran; H₂O / 24 h / 20 °C

4.1: H₂ / 10 percent Pd-C / methanol / 20 °C

With osmium(VIII) oxide; N-methyl-2-indolinone; hydrogen; sodium hydride; 3-chloro-benzenecarboperoxoic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; water;

DOI:10.3987/COM-00-9051

upstream raw materials:

ortho-nitrophenyl selenocyanate

10-deacetoxy-10-hydroxypropyl-7-O-triethylsilylbaccatin III

Downstream raw materials:

10-allyl-10-deacetoxy-7-O-triethylsilylbaccatin III

10-deacetoxy-10-formyl-7-O-13-O-bis-triethylsilylbaccatin III

10-deacetoxy-10-morpholinomethyl-7-O-triethylsilylbaccatin III

10-deacetoxy-7-O-13-O-bis-triethylsilyl-10-vinylbaccatin III