3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxylic acid hydrochloride

Base Information

• Chemical Name: 3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxylic acid hydrochloride
• CAS No.: 862559-73-7
• Molecular Formula: C₁₈H₁₉N₅O₃S*ClH
• Molecular Weight: 421.908
• Mol file: 862559-73-7.mol

Synonyms:3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxylic acid hydrochloride

Chemical Property of 3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxylic acid hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxylic acid hydrochloride

There total 1 articles about 3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxylic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl 3-([4-(4-methylpiperazin-1-yl)benzoyl]amino)-1H-thieno[2,3-c]pyrazole-5-carboxylate (862559-71-5) → 3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxylic acid hydrochloride (862559-73-7)

Guidance literature:

With hydrogenchloride; water; In 1,4-dioxane; at 20 ℃; for 16h;

Reference yield:

3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxylic acid hydrochloride (862559-73-7) + 2-phenyl-2-propylamine (585-32-0) → 3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (1-methyl-1-phenyl-ethyl)-amide

Guidance literature:

3-{[4-(4-methylpiperazin-1-yl)benzoyl]amino}-1H-thieno[2,3-c]pyrazole-5-carboxylic acid hydrochloride; With chloroformic acid ethyl ester; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 0 ℃; for 0.333333h;

2-phenyl-2-propylamine; In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃; for 16h;

With methanol; triethylamine; at 40 ℃; for 2h;

upstream raw materials:

tert-butyl 3-([4-(4-methylpiperazin-1-yl)benzoyl]amino)-1H-thieno[2,3-c]pyrazole-5-carboxylate