(S)-1-((E)-But-2-enyl)-5-[(E)-(1R,2R)-1-((E)-2-methoxy-vinyl)-4-phenyl-2-triethylsilanyloxy-but-3-enyl]-pyrrolidin-2-one

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Chemical Name:(S)-1-((E)-But-2-enyl)-5-[(E)-(1R,2R)-1-((E)-2-methoxy-vinyl)-4-phenyl-2-triethylsilanyloxy-but-3-enyl]-pyrrolidin-2-one
CAS No.:885972-14-5
Molecular Formula:C₂₇H₄₁NO₃Si
Molecular Weight:455.713
Hs Code.:

Synonyms:(S)-1-((E)-But-2-enyl)-5-[(E)-(1R,2R)-1-((E)-2-methoxy-vinyl)-4-phenyl-2-triethylsilanyloxy-but-3-enyl]-pyrrolidin-2-one

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Chemical Property of (S)-1-((E)-But-2-enyl)-5-[(E)-(1R,2R)-1-((E)-2-methoxy-vinyl)-4-phenyl-2-triethylsilanyloxy-but-3-enyl]-pyrrolidin-2-one

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Technology Process of (S)-1-((E)-But-2-enyl)-5-[(E)-(1R,2R)-1-((E)-2-methoxy-vinyl)-4-phenyl-2-triethylsilanyloxy-but-3-enyl]-pyrrolidin-2-one

There total 5 articles about (S)-1-((E)-But-2-enyl)-5-[(E)-(1R,2R)-1-((E)-2-methoxy-vinyl)-4-phenyl-2-triethylsilanyloxy-but-3-enyl]-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 885971-59-5
5-acetoxy N-crotyl pyyrolidine-2-one

: 885972-14-5
(S)-1-((E)-But-2-enyl)-5-[(E)-(1R,2R)-1-((E)-2-methoxy-vinyl)-4-phenyl-2-triethylsilanyloxy-but-3-enyl]-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: TiCl₄; diisopropylethylamine / CH₂Cl₂ / 0 - 30 °C

1.2: 92 percent / CH₂Cl₂ / 6 h / 0 °C

2.1: 74 percent / triethylamine; TMSCl / MgBr₂*OEt₂ / ethyl acetate / 36 h / 20 °C

3.1: 99 percent / 2,6-lutidine / CH₂Cl₂ / 20 °C

4.1: 96 percent / NaBH₄ / ethanol / 4 °C

5.1: 90 percent / 4-methylmorpholine N-oxide / TPAP / CH₂Cl₂ / 1 h / 20 °C

6.1: 76 percent / NaHMDS / tetrahydrofuran / 3 h / -78 °C

With 2,6-dimethylpyridine; sodium tetrahydroborate; chloro-trimethyl-silane; sodium hexamethyldisilazane; titanium tetrachloride; 4-methylmorpholine N-oxide; triethylamine; N-ethyl-N,N-diisopropylamine; tetrapropylammonium perruthennate; magnesium bromide; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; 6.1: Wittig reaction;
DOI:10.1021/jo052364l

Reference yield:

: 885971-66-4
(-)-5(S)-2[2-(4(R)-phenyl-2-thioxo-thiazolidine-3-yl)-2-oxo-ethyl]-1-(but-2-enyl)-pyrrolidine-2-one

: 885972-14-5
(S)-1-((E)-But-2-enyl)-5-[(E)-(1R,2R)-1-((E)-2-methoxy-vinyl)-4-phenyl-2-triethylsilanyloxy-but-3-enyl]-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 74 percent / triethylamine; TMSCl / MgBr₂*OEt₂ / ethyl acetate / 36 h / 20 °C

2: 99 percent / 2,6-lutidine / CH₂Cl₂ / 20 °C

3: 96 percent / NaBH₄ / ethanol / 4 °C

4: 90 percent / 4-methylmorpholine N-oxide / TPAP / CH₂Cl₂ / 1 h / 20 °C

5: 76 percent / NaHMDS / tetrahydrofuran / 3 h / -78 °C

With 2,6-dimethylpyridine; sodium tetrahydroborate; chloro-trimethyl-silane; sodium hexamethyldisilazane; 4-methylmorpholine N-oxide; triethylamine; tetrapropylammonium perruthennate; magnesium bromide; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; 5: Wittig reaction;
DOI:10.1021/jo052364l

Reference yield:

: 885971-87-9
(S)-1-((E)-But-2-enyl)-5-((E)-(1S,2R)-1-hydroxymethyl-4-phenyl-2-triethylsilanyloxy-but-3-enyl)-pyrrolidin-2-one

: 885972-14-5
(S)-1-((E)-But-2-enyl)-5-[(E)-(1R,2R)-1-((E)-2-methoxy-vinyl)-4-phenyl-2-triethylsilanyloxy-but-3-enyl]-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / 4-methylmorpholine N-oxide / TPAP / CH₂Cl₂ / 1 h / 20 °C

2: 76 percent / NaHMDS / tetrahydrofuran / 3 h / -78 °C

With sodium hexamethyldisilazane; 4-methylmorpholine N-oxide; tetrapropylammonium perruthennate; In tetrahydrofuran; dichloromethane; 2: Wittig reaction;
DOI:10.1021/jo052364l