Colforsin daropate hydrochloride

Base Information

Chemical Name:Colforsin daropate hydrochloride
CAS No.:138605-00-2
Molecular Formula:C₂₇H₄₃NO₈*ClH
Molecular Weight:546.101
Hs Code.:
European Community (EC) Number:689-002-6
UNII:C6P4R272GT
DSSTox Substance ID:DTXSID90930165
Wikipedia:Colforsin_daropate
Wikidata:Q5144763
Mol file:138605-00-2.mol

Synonyms:Coleonol;colforsin;Forskolin;N,N-dimethyl-beta-alanine-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho(2,1-b)pyran-6-yl ester HCl;NKH 477;NKH-477;NKH477

Suppliers and Price of Colforsin daropate hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
NKH 477
10mg
$ 502.00

TRC
NKH 477
50mg
$ 865.00

Tocris
NKH 477 ≥98%(HPLC)
50
$ 915.00

Tocris
NKH 477 ≥98%(HPLC)
10
$ 219.00

Sigma-Aldrich
NKH 477 ≥98% (HPLC), powder
5mg
$ 122.00

Sigma-Aldrich
NKH 477 ≥98% (HPLC), powder
25mg
$ 487.00

Sigma-Aldrich
Forskolin, NKH477 - CAS 138605-00-2 - Calbiochem
5 mg
$ 260.00

Sigma-Aldrich
Forskolin, NKH477
5mg-m
$ 260.00

ChemScene
NKH 477 ≥99.0%
50mg
$ 650.00

ChemScene
NKH 477 ≥99.0%
5mg
$ 100.00

Total 13 raw suppliers

Chemical Property of Colforsin daropate hydrochloride

Chemical Property:

Vapor Pressure:5.29E-16mmHg at 25°C
Boiling Point:571.4°Cat760mmHg
Flash Point:176°C
PSA：122.60000
Density:g/cm³
LogP:2.82450
Storage Temp.:Desiccate at +4°C
Solubility.:H2O: soluble3mg/mL, clear to slightly hazy (warmed)
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:8
Exact Mass:545.2755451
Heavy Atom Count:37
Complexity:933

Purity/Quality:

98%,99%, ^*data from raw suppliers

NKH 477 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:T+
Statements: 28
Safety Statements: 28-36/37-45

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)OC1C(C2C(CCC(C2(C3(C1(OC(CC3=O)(C)C=C)C)O)C)O)(C)C)OC(=O)CCN(C)C.Cl
Isomeric SMILES:CC(=O)O[C@H]1[C@H]([C@@H]2[C@]([C@H](CCC2(C)C)O)([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)OC(=O)CCN(C)C.Cl
Description Colforsin daropate was launched in Japan as a treatment for acute heart failure. It is a water-soluble and orally active 3-dimethylaminopropionyl (daropate) derivative of forskolin, a labdane-type diterpene isolated from the root of Coleus forskohlii. It is obtained from forskolin in 7 steps based upon a series of protections and deprotections of the different OH groups and a key 7,8- transacylation. Colforsin daropate is the first in its class of adenylate cyclase activators to be marketed in the treatment of heart failure. As forskolin, it directly stimulates adenylate cyclase thus increasing intracellular concentration of cAMP and inhibiting calcium mobilization. As a direct consequence, it induces a significant vasodilatation, so provides a moderate positive inotropic and chronotropic effect. In contrast with well-established generators of cAMP synthesis (dobutamine), Colforsin daropate maintains its action on cardiac muscle in the severe stage even when the beta-adrenoceptor is down-regulated in myocardium. In several clinical trials in patients with severe congestive heart failure (CHF), Colforsin daproate improved hemodynamic symptoms of heart failure patients without serious adverse effects.
Uses NKH 477 is a water-soluble analog of Forskolin (F701800), that is a potent activator of adenylyl cyclase, which shows some selectivity for cardiac (type V) adenylyl cyclase).

Technology Process of Colforsin daropate hydrochloride

There total 1 articles about Colforsin daropate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: