Acetic acid (1S,5R,6S,8S)-8-methyl-6-phenyl-8-aza-bicyclo[3.2.1]oct-6-yl ester

Base Information

Chemical Name:Acetic acid (1S,5R,6S,8S)-8-methyl-6-phenyl-8-aza-bicyclo[3.2.1]oct-6-yl ester
CAS No.:100986-37-6
Molecular Formula:C₁₆H₂₁NO₂
Molecular Weight:259.348
Hs Code.:

Synonyms:Acetic acid (1S,5R,6S,8S)-8-methyl-6-phenyl-8-aza-bicyclo[3.2.1]oct-6-yl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Acetic acid (1S,5R,6S,8S)-8-methyl-6-phenyl-8-aza-bicyclo[3.2.1]oct-6-yl ester

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Technology Process of Acetic acid (1S,5R,6S,8S)-8-methyl-6-phenyl-8-aza-bicyclo[3.2.1]oct-6-yl ester

There total 7 articles about Acetic acid (1S,5R,6S,8S)-8-methyl-6-phenyl-8-aza-bicyclo[3.2.1]oct-6-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 108-24-7
acetic anhydride

: 77923-96-7
6β-phenyl-8-methyl-6α-hydroxy-8-azabicyclo<3.2.1>octane

: 100986-37-6
Acetic acid (1S,5R,6S,8S)-8-methyl-6-phenyl-8-aza-bicyclo[3.2.1]oct-6-yl ester

Guidance literature:: With toluene-4-sulfonic acid; at 110 ℃; for 96h;

Reference yield:

: 542-05-2
acetonedicarboxylic acid

: 100986-37-6
Acetic acid (1S,5R,6S,8S)-8-methyl-6-phenyl-8-aza-bicyclo[3.2.1]oct-6-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: sodium acetate, HCl, K₂CO₃ / H₂O / 48 h / Ambient temperature; pH=4-5

2: hydrazine hydrate / ethanol / 3 h / 120 °C

3: KOH / 130 degC, 1 h; 160 degC, 2 h; 190 degC, 1.5 h

4: 48 percent / chromium trioxide / acetic acid / 70-80 degC, 16 h; 100 degC, 2 h

5: 1.) THF, reflux, 2 d; 2.) THF/ether, 5 degC, 1 h

With chromium(VI) oxide; hydrogenchloride; potassium hydroxide; sodium acetate; potassium carbonate; hydrazine hydrate; In ethanol; water; acetic acid;

Reference yield:

: 18700-21-5,18700-23-7,126120-91-0
6β-hydroxy-8-methyl-8-azabicyclo<3.2.1>octane

: 100986-37-6
Acetic acid (1S,5R,6S,8S)-8-methyl-6-phenyl-8-aza-bicyclo[3.2.1]oct-6-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 48 percent / chromium trioxide / acetic acid / 70-80 degC, 16 h; 100 degC, 2 h

2: 1.) THF, reflux, 2 d; 2.) THF/ether, 5 degC, 1 h

With chromium(VI) oxide; In acetic acid;