5-[4-(3,3,3-trifluoropropylsulfonylmethyl)cycohexenyl]-4-pentynic acid methyl ester

Base Information

Chemical Name:5-[4-(3,3,3-trifluoropropylsulfonylmethyl)cycohexenyl]-4-pentynic acid methyl ester
CAS No.:1098304-91-6
Molecular Formula:C₁₆H₂₃F₃O₄S
Molecular Weight:368.417
Hs Code.:

Synonyms:5-[4-(3,3,3-trifluoropropylsulfonylmethyl)cycohexenyl]-4-pentynic acid methyl ester

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Chemical Property of 5-[4-(3,3,3-trifluoropropylsulfonylmethyl)cycohexenyl]-4-pentynic acid methyl ester

Chemical Property:

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Technology Process of 5-[4-(3,3,3-trifluoropropylsulfonylmethyl)cycohexenyl]-4-pentynic acid methyl ester

There total 3 articles about 5-[4-(3,3,3-trifluoropropylsulfonylmethyl)cycohexenyl]-4-pentynic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1233934-92-3
1-(2,2-dibromovinyl)-4-(3,3,3-trifluoropropylsulfonylmethyl)cyclohexane

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: 1098304-91-6
5-[4-(3,3,3-trifluoropropylsulfonylmethyl)cycohexenyl]-4-pentynic acid methyl ester

Guidance literature:: 1-(2,2-dibromovinyl)-4-(3,3,3-trifluoropropylsulfonylmethyl)cyclohexane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - -50 ℃; for 1.16667h;

acrylic acid methyl ester; In tetrahydrofuran; hexane; at 0 ℃; for 2h;

Reference yield:

: 1233934-88-7
4-(3,3,3-trifluoropropylsulfonylmethyl)cyclohexanemethanol

: 1098304-91-6
5-[4-(3,3,3-trifluoropropylsulfonylmethyl)cycohexenyl]-4-pentynic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 2 h / -78 - -50 °C / Inert atmosphere

1.2: 18.67 h / -50 - 20 °C / Inert atmosphere

2.1: triphenylphosphine / dichloromethane / 1 h / 0 °C / Inert atmosphere

2.2: 6.5 h / 0 - 20 °C / Inert atmosphere

3.1: n-butyllithium / hexane; tetrahydrofuran / 1.17 h / -78 - -50 °C / Inert atmosphere

3.2: 2 h / -50 - 0 °C / Inert atmosphere

With n-butyllithium; oxalyl dichloride; dimethyl sulfoxide; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane;

Reference yield:

: 1233934-90-1
4-(3,3,3-trifluoropropanesulfonylmethyl)cyclohexane carbaldehyde

: 1098304-91-6
5-[4-(3,3,3-trifluoropropylsulfonylmethyl)cycohexenyl]-4-pentynic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine / dichloromethane / 1 h / 0 °C / Inert atmosphere

1.2: 6.5 h / 0 - 20 °C / Inert atmosphere

2.1: n-butyllithium / hexane; tetrahydrofuran / 1.17 h / -78 - -50 °C / Inert atmosphere

2.2: 2 h / -50 - 0 °C / Inert atmosphere

With n-butyllithium; triphenylphosphine; In tetrahydrofuran; hexane; dichloromethane;