11-acetoxy-11-(2-tert-butyldimethylsilyloxy-4,5-methylenedioxy)phenyl-driman-8α-ol

Base Information

• Chemical Name: 11-acetoxy-11-(2-tert-butyldimethylsilyloxy-4,5-methylenedioxy)phenyl-driman-8α-ol
• CAS No.: 257288-20-3
• Molecular Formula: C₃₀H₄₈O₆Si
• Molecular Weight: 532.793
• Mol file: 257288-20-3.mol

Synonyms:11-acetoxy-11-(2-tert-butyldimethylsilyloxy-4,5-methylenedioxy)phenyl-driman-8α-ol

Chemical Property of 11-acetoxy-11-(2-tert-butyldimethylsilyloxy-4,5-methylenedioxy)phenyl-driman-8α-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 11-acetoxy-11-(2-tert-butyldimethylsilyloxy-4,5-methylenedioxy)phenyl-driman-8α-ol

There total 1 articles about 11-acetoxy-11-(2-tert-butyldimethylsilyloxy-4,5-methylenedioxy)phenyl-driman-8α-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

8α-acetoxydriman-11-al (165816-95-5) + 2-bromo-1-tert-butyldimethylsilyloxy-4,5-methylenedioxybenzene (197522-65-9) → (1'S,6'S)-4-[2',2',6'-trimethyl-6'-(2''-hydroxy-4'',5''-methylenedioxyphenylvinyl)cyclohexyl]-2-butanone + 6-(8α-hydroxydriman-11-yliden)-3,4-methylenedioxy-2,4-cyclohexadienone + 11-acetoxy-11-(2-tert-butyldimethylsilyloxy-4,5-methylenedioxy)phenyl-driman-8α-ol (257288-20-3)

Guidance literature:

With tert.-butyl lithium; In diethyl ether; pentane; at -78 ℃; for 0.75h;

DOI:10.1016/S0040-4020(99)00992-8

Reference yield: 95.0%

11-acetoxy-11-(2-tert-butyldimethylsilyloxy-4,5-methylenedioxy)phenyl-driman-8α-ol (257288-20-3) → (1'S,6'S)-4-[2',2',6'-trimethyl-6'-(2''-hydroxy-4'',5''-methylenedioxyphenylvinyl)cyclohexyl]-2-butanone

Guidance literature:

With Amberlyst A-15; In tetrahydrofuran; for 0.75h; Heating;

DOI:10.1016/S0040-4020(99)00992-8

Reference yield: 92.0%

11-acetoxy-11-(2-tert-butyldimethylsilyloxy-4,5-methylenedioxy)phenyl-driman-8α-ol (257288-20-3) → 4-((1S,2R)-2-{(E)-2-[6-(tert-Butyl-dimethyl-silanyloxy)-benzo[1,3]dioxol-5-yl]-vinyl}-2,6,6-trimethyl-cyclohexyl)-butan-2-one

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 60 ℃; for 2h;

DOI:10.1016/S0040-4020(99)00992-8

upstream raw materials:

8α-acetoxydriman-11-al

2-bromo-1-tert-butyldimethylsilyloxy-4,5-methylenedioxybenzene