Technology Process of (2E)-3-(4-hexyl-3-propylphenyl)acrylaldehyde
There total 6 articles about (2E)-3-(4-hexyl-3-propylphenyl)acrylaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
N-tert-butyl-2-(triethylsilyl)acetaldimine;
With
lithium diisopropyl amide;
In
tetrahydrofuran; cyclohexane;
at 0 ℃;
for 0.5h;
4-hexyl-3-propylbenzaldehyde;
In
tetrahydrofuran; cyclohexane;
at -78 - 20 ℃;
for 3.5h;
With
citric acid;
In
tetrahydrofuran; cyclohexane;
for 16h;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine / 1,3-bis-(diphenylphosphino)propane / N,N-dimethyl-formamide / 16 h / 95 °C
2.1: hydrogen / palladium on carbon / ethanol / 16 h / 20 °C
3.1: diisobutylaluminium hydride / dichloromethane / 20 h / -78 - 20 °C
4.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane; acetonitrile / 2 h / 20 °C / Molecular sieve
5.1: lithium diisopropyl amide / cyclohexane; tetrahydrofuran / 0.5 h / 0 °C
5.2: 3.5 h / -78 - 20 °C
5.3: 16 h
With
tetrapropylammonium perruthennate; hydrogen; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; triethylamine; lithium diisopropyl amide;
palladium on carbon; 1,3-bis-(diphenylphosphino)propane;
In
tetrahydrofuran; ethanol; dichloromethane; cyclohexane; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine / 1,3-bis-(diphenylphosphino)propane / N,N-dimethyl-formamide / 16 h / 95 °C
2.1: hydrogen / palladium on carbon / ethanol / 16 h / 20 °C
3.1: diisobutylaluminium hydride / dichloromethane / 20 h / -78 - 20 °C
4.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane; acetonitrile / 2 h / 20 °C / Molecular sieve
5.1: lithium diisopropyl amide / cyclohexane; tetrahydrofuran / 0.5 h / 0 °C
5.2: 3.5 h / -78 - 20 °C
5.3: 16 h
With
tetrapropylammonium perruthennate; hydrogen; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; triethylamine; lithium diisopropyl amide;
palladium on carbon; 1,3-bis-(diphenylphosphino)propane;
In
tetrahydrofuran; ethanol; dichloromethane; cyclohexane; N,N-dimethyl-formamide; acetonitrile;
