4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methoxy-benzoic acid methyl ester

Base Information

• Chemical Name: 4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methoxy-benzoic acid methyl ester
• CAS No.: 219685-61-7
• Molecular Formula: C₂₄H₂₁NO₅
• Molecular Weight: 403.434
• Mol file: 219685-61-7.mol

Synonyms:4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methoxy-benzoic acid methyl ester

Chemical Property of 4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methoxy-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methoxy-benzoic acid methyl ester

There total 1 articles about 4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methoxy-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methyl 3-methoxy-4-aminobenzoate (41608-64-4) + N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) → 4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methoxy-benzoic acid methyl ester (219685-61-7)

Guidance literature:

In water; acetonitrile; Heating;

DOI:10.1021/jm0208572

Reference yield:

4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methoxy-benzoic acid methyl ester (219685-61-7) → (4-hydroxymethyl-2-methoxy-phenyl)-carbamic acid 9H-fluoren-9-ylmethyl ester (591753-18-3)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; toluene; at 0 - 20 ℃;

DOI:10.1021/jm0208572

Reference yield:

4-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methoxy-benzoic acid methyl ester (219685-61-7) → (4-Formyl-2-methoxyphenyl)carbamic acid 9H-fluoren-9-ylmethyl ester (219685-60-6)

Guidance literature:

Multi-step reaction with 2 steps

1: diisobutylaluminum hydride / CH₂Cl₂; toluene / 0 - 20 °C

2: MnO₂ / CH₂Cl₂ / 20 °C

With manganese(IV) oxide; diisobutylaluminium hydride; In dichloromethane; toluene;

DOI:10.1021/jm0208572

upstream raw materials:

methyl 3-methoxy-4-aminobenzoate

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide

Downstream raw materials:

(4-hydroxymethyl-2-methoxy-phenyl)-carbamic acid 9H-fluoren-9-ylmethyl ester

(4-Formyl-2-methoxyphenyl)carbamic acid 9H-fluoren-9-ylmethyl ester