5-tert-Butylcarbamoyl-2,3-dihydro-pyrazine-1,4-dicarboxylic acid 4-benzyl ester 1-tert-butyl ester

Base Information

• Chemical Name: 5-tert-Butylcarbamoyl-2,3-dihydro-pyrazine-1,4-dicarboxylic acid 4-benzyl ester 1-tert-butyl ester
• CAS No.: 171504-92-0
• Molecular Formula: C₂₂H₃₁N₃O₅
• Molecular Weight: 417.505
• Mol file: 171504-92-0.mol

Synonyms:5-tert-Butylcarbamoyl-2,3-dihydro-pyrazine-1,4-dicarboxylic acid 4-benzyl ester 1-tert-butyl ester

Chemical Property of 5-tert-Butylcarbamoyl-2,3-dihydro-pyrazine-1,4-dicarboxylic acid 4-benzyl ester 1-tert-butyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of 5-tert-Butylcarbamoyl-2,3-dihydro-pyrazine-1,4-dicarboxylic acid 4-benzyl ester 1-tert-butyl ester

There total 1 articles about 5-tert-Butylcarbamoyl-2,3-dihydro-pyrazine-1,4-dicarboxylic acid 4-benzyl ester 1-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

di-tert-butyl dicarbonate (24424-99-5) + 6-tert-Butylcarbamoyl-3,4-dihydro-2H-pyrazine-1-carboxylic acid benzyl ester → 5-tert-Butylcarbamoyl-2,3-dihydro-pyrazine-1,4-dicarboxylic acid 4-benzyl ester 1-tert-butyl ester (171504-92-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In various solvent(s); for 18h; Heating;

DOI:10.1016/0040-4039(95)01345-I

Reference yield: 96.0%

5-tert-Butylcarbamoyl-2,3-dihydro-pyrazine-1,4-dicarboxylic acid 4-benzyl ester 1-tert-butyl ester (171504-92-0) → N-tert-butyl-4-<(1,1-dimethylethoxy)carbonyl>-1-<(phenylmethyl)carbonyl>piperazine-2(S)-carboxamide (150323-34-5)

Guidance literature:

With hydrogen; <(R)-BINAP(COD)Rh>OTf; In methanol; at 40 ℃; for 18h; under 52504.2 Torr;

DOI:10.1016/0040-4039(95)01345-I

Reference yield: 16.0%

5-tert-Butylcarbamoyl-2,3-dihydro-pyrazine-1,4-dicarboxylic acid 4-benzyl ester 1-tert-butyl ester (171504-92-0) → 1-benzyloxycarbonyl-4-tert-butoxycarbonylpiperazine-2-(N-tert-butyl)carboxamide

Guidance literature:

With PF6; (S,S)-2,2''-bis<(R)-1-(dimethylphosphino)ethyl>-1,1''-biferrocene; hydrogen; In 1,2-dichloro-ethane; at 50 ℃; for 24h; under 735.508 Torr;

DOI:10.1021/jo981939u

upstream raw materials:

di-tert-butyl dicarbonate

Downstream raw materials:

N-tert-butyl-4-<(1,1-dimethylethoxy)carbonyl>-1-<(phenylmethyl)carbonyl>piperazine-2(S)-carboxamide

Refernces