N-3-[(2-(4-hydroxyphenyl)-4-oxo-1,3-thiazolidin-3-yl)carbamyl]propyl-2-aminothiazole

Base Information

• Chemical Name: N-3-[(2-(4-hydroxyphenyl)-4-oxo-1,3-thiazolidin-3-yl)carbamyl]propyl-2-aminothiazole
• CAS No.: 1391823-31-6
• Molecular Formula: C₁₆H₁₈N₄O₃S₂
• Molecular Weight: 378.476

Synonyms:N-3-[(2-(4-hydroxyphenyl)-4-oxo-1,3-thiazolidin-3-yl)carbamyl]propyl-2-aminothiazole

Chemical Property of N-3-[(2-(4-hydroxyphenyl)-4-oxo-1,3-thiazolidin-3-yl)carbamyl]propyl-2-aminothiazole

Chemical Property:

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Technology Process of N-3-[(2-(4-hydroxyphenyl)-4-oxo-1,3-thiazolidin-3-yl)carbamyl]propyl-2-aminothiazole

There total 2 articles about N-3-[(2-(4-hydroxyphenyl)-4-oxo-1,3-thiazolidin-3-yl)carbamyl]propyl-2-aminothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

N-{3-(4-hydroxybenzylidencarbamyl)-propyl}-2-aminothiazole (1268706-06-4) + mercaptoacetic acid (68-11-1) → N-3-[(2-(4-hydroxyphenyl)-4-oxo-1,3-thiazolidin-3-yl)carbamyl]propyl-2-aminothiazole (1391823-31-6)

Guidance literature:

With zinc(II) chloride; In methanol; at 80 - 90 ℃;

DOI:10.1007/s12039-011-0123-2

Reference yield:

N-(3-chloropropyl)-2-aminothiazole (1268705-87-8) → N-3-[(2-(4-hydroxyphenyl)-4-oxo-1,3-thiazolidin-3-yl)carbamyl]propyl-2-aminothiazole (1391823-31-6)

Guidance literature:

Multi-step reaction with 3 steps

1: methanol / 8 h / 20 °C

2: methanol / 20 °C / Heating

3: zinc(II) chloride / methanol / 80 - 90 °C

With zinc(II) chloride; In methanol;

DOI:10.1007/s12039-011-0123-2

Reference yield: 65.0%

N-3-[(2-(4-hydroxyphenyl)-4-oxo-1,3-thiazolidin-3-yl)carbamyl]propyl-2-aminothiazole (1391823-31-6) + 4-hydroxy-benzaldehyde (123-08-0,65581-83-1) → N-3-[{2-(4-hydroxyphenyl)-4-oxo-5-(4-hydroxybenzylidene)-1,3-thiazolidin-3-yl}carbamyl]propyl-2-aminothiazole (1391823-50-9)

Guidance literature:

With sodium ethanolate; In methanol; at 80 - 90 ℃;

DOI:10.1007/s12039-011-0123-2

upstream raw materials:

N-{3-(4-hydroxybenzylidencarbamyl)-propyl}-2-aminothiazole

mercaptoacetic acid

N-(3-chloropropyl)-2-aminothiazole

Downstream raw materials:

N-3-[{2-(4-hydroxyphenyl)-4-oxo-5-(4-hydroxybenzylidene)-1,3-thiazolidin-3-yl}carbamyl]propyl-2-aminothiazole

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