2-(3-(4-(tert-butoxycarbonylamino)benzyl)ureido)-3-(3-hydroxyphenyl)propanoic acid

Base Information

Chemical Name:2-(3-(4-(tert-butoxycarbonylamino)benzyl)ureido)-3-(3-hydroxyphenyl)propanoic acid
CAS No.:1313214-13-9
Molecular Formula:C₂₂H₂₇N₃O₆
Molecular Weight:429.473
Hs Code.:

Synonyms:2-(3-(4-(tert-butoxycarbonylamino)benzyl)ureido)-3-(3-hydroxyphenyl)propanoic acid

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Chemical Property of 2-(3-(4-(tert-butoxycarbonylamino)benzyl)ureido)-3-(3-hydroxyphenyl)propanoic acid

Chemical Property:

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Technology Process of 2-(3-(4-(tert-butoxycarbonylamino)benzyl)ureido)-3-(3-hydroxyphenyl)propanoic acid

There total 6 articles about 2-(3-(4-(tert-butoxycarbonylamino)benzyl)ureido)-3-(3-hydroxyphenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1313214-12-8
benzyl 3-(3-(benzyloxy)phenyl)-2-(3-(4-(tert-butoxycarbonylamino)benzyl)ureido)propanoate

: 1313214-13-9
2-(3-(4-(tert-butoxycarbonylamino)benzyl)ureido)-3-(3-hydroxyphenyl)propanoic acid

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; for 1h;

Reference yield:

: 1313214-10-6
benzyl 2-(tert-butoxycarbonylamino)-3-(3-hydroxyphenyl)propanoate

: 1313214-13-9
2-(3-(4-(tert-butoxycarbonylamino)benzyl)ureido)-3-(3-hydroxyphenyl)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / acetone / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.1: ethyl acetate / -10 °C / Reflux

3.2: 20 °C

4.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h

With hydrogen; potassium carbonate; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; ethyl acetate; acetone;

Reference yield:

: 775-06-4,29562-33-2
D/L-3-hydroxy-phenylalanine

: 1313214-13-9
2-(3-(4-(tert-butoxycarbonylamino)benzyl)ureido)-3-(3-hydroxyphenyl)propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / -5 °C

1.2: -5 - 120 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C

3.1: potassium carbonate / acetone / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

5.1: ethyl acetate / -10 °C / Reflux

5.2: 20 °C

6.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h

With thionyl chloride; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; ethyl acetate; acetone;