[(2R,4S,5R)-2-(4-Methoxy-phenyl)-4-vinyl-[1,3]dioxan-5-yloxy]-acetic acid tert-butyl ester

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Chemical Name:[(2R,4S,5R)-2-(4-Methoxy-phenyl)-4-vinyl-[1,3]dioxan-5-yloxy]-acetic acid tert-butyl ester
CAS No.:330954-53-5
Molecular Formula:C₁₉H₂₆O₆
Molecular Weight:350.412
Hs Code.:

Synonyms:[(2R,4S,5R)-2-(4-Methoxy-phenyl)-4-vinyl-[1,3]dioxan-5-yloxy]-acetic acid tert-butyl ester

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Chemical Property of [(2R,4S,5R)-2-(4-Methoxy-phenyl)-4-vinyl-[1,3]dioxan-5-yloxy]-acetic acid tert-butyl ester

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Technology Process of [(2R,4S,5R)-2-(4-Methoxy-phenyl)-4-vinyl-[1,3]dioxan-5-yloxy]-acetic acid tert-butyl ester

There total 4 articles about [(2R,4S,5R)-2-(4-Methoxy-phenyl)-4-vinyl-[1,3]dioxan-5-yloxy]-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 5292-43-3
bromoacetic acid tert-butyl ester

: 440320-33-2
(2R,4S,5R)-2-(4-Methoxy-phenyl)-4-vinyl-[1,3]dioxan-5-ol

: 330954-53-5
[(2R,4S,5R)-2-(4-Methoxy-phenyl)-4-vinyl-[1,3]dioxan-5-yloxy]-acetic acid tert-butyl ester

Guidance literature:: (2R,4S,5R)-2-(4-Methoxy-phenyl)-4-vinyl-[1,3]dioxan-5-ol; With sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

bromoacetic acid tert-butyl ester; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1016/S0040-4020(02)00041-8

Reference yield:

: 4,6-O-(p-methoxybenzylidene)-D-glucopyranose

: 330954-53-5
[(2R,4S,5R)-2-(4-Methoxy-phenyl)-4-vinyl-[1,3]dioxan-5-yloxy]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: aq. NaOAc; acetic acid; NaIO₄ / methanol / 2 h / 20 °C

2.1: 85.5 g / t-BuOK / tetrahydrofuran / 2 h / 0 °C

3.1: NaH / tetrahydrofuran; dimethylformamide / 0.33 h / 20 °C

3.2: 99 percent / tetrahydrofuran; dimethylformamide / 24 h / 20 °C

With sodium periodate; potassium tert-butylate; sodium acetate; sodium hydride; acetic acid; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 2.1: Wittig reaction;
DOI:10.1016/S0040-4020(02)00041-8

Reference yield:

: 440320-44-5
(2R,4R,5R)-5-Hydroxy-2-(4-methoxy-phenyl)-[1,3]dioxane-4-carbaldehyde

: 330954-53-5
[(2R,4S,5R)-2-(4-Methoxy-phenyl)-4-vinyl-[1,3]dioxan-5-yloxy]-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 85.5 g / t-BuOK / tetrahydrofuran / 2 h / 0 °C

2.1: NaH / tetrahydrofuran; dimethylformamide / 0.33 h / 20 °C

2.2: 99 percent / tetrahydrofuran; dimethylformamide / 24 h / 20 °C

With potassium tert-butylate; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide; 1.1: Wittig reaction;
DOI:10.1016/S0040-4020(02)00041-8