{(1R,2S)-1-[3,5-dimethoxy-4-((S)-oct-1-en-4-yl)phenyl]-2-methylpent-4-enyloxy}triethylsilane

Base Information

Chemical Name:{(1R,2S)-1-[3,5-dimethoxy-4-((S)-oct-1-en-4-yl)phenyl]-2-methylpent-4-enyloxy}triethylsilane
CAS No.:277297-39-9
Molecular Formula:C₂₈H₄₈O₃Si
Molecular Weight:460.773
Hs Code.:

Synonyms:{(1R,2S)-1-[3,5-dimethoxy-4-((S)-oct-1-en-4-yl)phenyl]-2-methylpent-4-enyloxy}triethylsilane

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Chemical Property of {(1R,2S)-1-[3,5-dimethoxy-4-((S)-oct-1-en-4-yl)phenyl]-2-methylpent-4-enyloxy}triethylsilane

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Technology Process of {(1R,2S)-1-[3,5-dimethoxy-4-((S)-oct-1-en-4-yl)phenyl]-2-methylpent-4-enyloxy}triethylsilane

There total 5 articles about {(1R,2S)-1-[3,5-dimethoxy-4-((S)-oct-1-en-4-yl)phenyl]-2-methylpent-4-enyloxy}triethylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1192065-33-0
(1R,2S)-5-{3,5-dimethoxy-4-[(S)-oct-1-en-4-yl]phenyl}-4-methyl-5-triethylsilyloxypentan-1-ol

: 277297-39-9
{(1R,2S)-1-[3,5-dimethoxy-4-((S)-oct-1-en-4-yl)phenyl]-2-methylpent-4-enyloxy}triethylsilane

Guidance literature:: (1R,2S)-5-{3,5-dimethoxy-4-[(S)-oct-1-en-4-yl]phenyl}-4-methyl-5-triethylsilyloxypentan-1-ol; With ortho-nitrophenyl selenocyanate; tributylphosphine; In tetrahydrofuran; at 0 ℃; for 3h; Inert atmosphere;

With dihydrogen peroxide; In tetrahydrofuran; water; at 0 ℃; for 8.16667h; Inert atmosphere;
DOI:10.1039/b909646a

Reference yield: 92.0%

: triethylsilyl trifluoromethanesulfonate

: (S)-1-[4-((S)-1-Allyl-pentyl)-3,5-dimethoxy-phenyl]-2-methyl-pent-4-en-1-ol

: 277297-39-9
{(1R,2S)-1-[3,5-dimethoxy-4-((S)-oct-1-en-4-yl)phenyl]-2-methylpent-4-enyloxy}triethylsilane

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃; for 0.25h;
DOI:10.1021/ja0106164

Reference yield:

: 277297-37-7
(2S)-N-[1R,2R]-(2-hydroxy-1-methyl-2-phenylethyl)-N,2-dimethyl-4-pentenamide

: 277297-39-9
{(1R,2S)-1-[3,5-dimethoxy-4-((S)-oct-1-en-4-yl)phenyl]-2-methylpent-4-enyloxy}triethylsilane

Guidance literature:: Multi-step reaction with 3 steps

1.1: t-BuLi / tetrahydrofuran; pentane / -78 °C

1.2: t-Buli / tetrahydrofuran; pentane / 0.4 h / -78 - 0 °C

1.3: 68 percent / diisopropylamine / tetrahydrofuran; pentane / 0.08 h / 0 °C

2.1: 81 percent / (+)-B-chlorodiisopinocampheylborane / tetrahydrofuran / 86 h / 0 - 20 °C

3.1: 92 percent / 2,6-lutidine / CH₂Cl₂ / 0.25 h / 0 °C

With 2,6-dimethylpyridine; (+)-β-chlorodiisopinocampheylborane; tert.-butyl lithium; In tetrahydrofuran; dichloromethane; pentane;
DOI:10.1021/ja0106164