6,7,8,9-tetrahydro-9-hydroxy5-(4-methylphenylsulfonyl)-5H-pyrido[3,2-b]azepine

Base Information

Chemical Name:6,7,8,9-tetrahydro-9-hydroxy5-(4-methylphenylsulfonyl)-5H-pyrido[3,2-b]azepine
CAS No.:269404-06-0
Molecular Formula:C₁₆H₁₈N₂O₃S
Molecular Weight:318.397
Hs Code.:

Synonyms:6,7,8,9-tetrahydro-9-hydroxy5-(4-methylphenylsulfonyl)-5H-pyrido[3,2-b]azepine

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Chemical Property of 6,7,8,9-tetrahydro-9-hydroxy5-(4-methylphenylsulfonyl)-5H-pyrido[3,2-b]azepine

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Technology Process of 6,7,8,9-tetrahydro-9-hydroxy5-(4-methylphenylsulfonyl)-5H-pyrido[3,2-b]azepine

There total 5 articles about 6,7,8,9-tetrahydro-9-hydroxy5-(4-methylphenylsulfonyl)-5H-pyrido[3,2-b]azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 269404-05-9
6,7,8,9-tetrahydro-9-hydroxy-5-(4-methylphenylsulfonyl)-5H-pyrido[3,2-b]azepine O-acetate

: 6,7-dihydro-5-(4-methylphenylsulfonyl)-5H-pyrido[3,2-b]azepine

: 269404-06-0
6,7,8,9-tetrahydro-9-hydroxy5-(4-methylphenylsulfonyl)-5H-pyrido[3,2-b]azepine

Guidance literature:: With potassium carbonate; In tetrahydrofuran; methanol; at 20 ℃;
DOI:10.1002/jhet.5570370107

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 269404-06-0
6,7,8,9-tetrahydro-9-hydroxy5-(4-methylphenylsulfonyl)-5H-pyrido[3,2-b]azepine

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / N,N-diisopropylethylamine / CH₂Cl₂ / 20 °C

2: 3-chloroperoxybenzoic acid / CH₂Cl₂ / 20 °C

3: 84 percent / toluene / 5 h / Heating

4: 74 percent / potassium carbonate / tetrahydrofuran; methanol / 20 °C

With potassium carbonate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; methanol; dichloromethane; toluene; 1: Tosylation / 2: Oxidation / 3: Acetoxylation / 4: Hydrolysis;
DOI:10.1002/jhet.5570370107

Reference yield:

: 269404-04-8
6,7,8,9-tetrahydro-5-(4-methylphenylsulfonyl)-5H-pyrido[3,2-b]azepine N-oxide

: 269404-06-0
6,7,8,9-tetrahydro-9-hydroxy5-(4-methylphenylsulfonyl)-5H-pyrido[3,2-b]azepine

Guidance literature:: Multi-step reaction with 2 steps

1: 84 percent / toluene / 5 h / Heating

2: 74 percent / potassium carbonate / tetrahydrofuran; methanol / 20 °C

With potassium carbonate; In tetrahydrofuran; methanol; toluene; 1: Acetoxylation / 2: Hydrolysis;
DOI:10.1002/jhet.5570370107