C₁₈H₁₀ClF₂N₃O

Base Information

Chemical Name:C₁₈H₁₀ClF₂N₃O
CAS No.:1190735-62-6
Molecular Formula:C₁₈H₁₀ClF₂N₃O
Molecular Weight:357.747
Hs Code.:

C<sub>18</sub>H<sub>10</sub>ClF<sub>2</sub>N<sub>3</sub>O

Synonyms:C₁₈H₁₀ClF₂N₃O

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Chemical Property of C₁₈H₁₀ClF₂N₃O

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Technology Process of C₁₈H₁₀ClF₂N₃O

There total 8 articles about C₁₈H₁₀ClF₂N₃O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1190735-61-5
C₁₈H₁₂ClF₂N₃O₂

: 1190735-62-6
C₁₈H₁₀ClF₂N₃O

Guidance literature:: With pyridine; trifluoroacetic anhydride; In chloroform; at 20 ℃; for 1.5h;

Reference yield:

: 110888-15-8
4-chloro-3-fluorobenzonitrile

: 1190735-62-6
C₁₈H₁₀ClF₂N₃O

Guidance literature:: Multi-step reaction with 8 steps

1.1: trimethylaluminum; ammonium chloride / toluene / 80 °C / Inert atmosphere

2.1: sodium ethanolate / ethanol / 3 h / Reflux

3.1: trichlorophosphate / N,N-dimethyl-aniline / 22 h / Reflux

4.1: sodium hydride / tetrahydrofuran / -78 - 20 °C

5.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 2 h / Reflux; Inert atmosphere

6.1: water; sodium hydroxide / ethanol / 20 °C

7.1: oxalyl dichloride; N,N-dimethyl-formamide / chloroform / 1 h / 20 °C

7.2: 1 h / 20 °C

8.1: pyridine; trifluoroacetic anhydride / chloroform / 1.5 h / 20 °C

With pyridine; oxalyl dichloride; water; trimethylaluminum; sodium ethanolate; sodium hydride; sodium carbonate; ammonium chloride; N,N-dimethyl-formamide; trifluoroacetic anhydride; sodium hydroxide; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; chloroform; water; N,N-dimethyl-aniline; toluene;

Reference yield:

: 1190735-16-0
4-chloro-3-fluorobenzamidine hydrochloride

: 1190735-62-6
C₁₈H₁₀ClF₂N₃O

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium ethanolate / ethanol / 3 h / Reflux

2.1: trichlorophosphate / N,N-dimethyl-aniline / 22 h / Reflux

3.1: sodium hydride / tetrahydrofuran / -78 - 20 °C

4.1: sodium carbonate / bis-triphenylphosphine-palladium(II) chloride / 1,2-dimethoxyethane; water / 2 h / Reflux; Inert atmosphere

5.1: water; sodium hydroxide / ethanol / 20 °C

6.1: oxalyl dichloride; N,N-dimethyl-formamide / chloroform / 1 h / 20 °C

6.2: 1 h / 20 °C

7.1: pyridine; trifluoroacetic anhydride / chloroform / 1.5 h / 20 °C

With pyridine; oxalyl dichloride; water; sodium ethanolate; sodium hydride; sodium carbonate; N,N-dimethyl-formamide; trifluoroacetic anhydride; sodium hydroxide; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; chloroform; water; N,N-dimethyl-aniline;