4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-2-(6-methoxy-5-nitro-quinolin-2-yl)-5,6-dimethyl-nicotinic acid

Base Information

Chemical Name:4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-2-(6-methoxy-5-nitro-quinolin-2-yl)-5,6-dimethyl-nicotinic acid
CAS No.:77405-74-4
Molecular Formula:C₃₃H₂₉N₃O₈
Molecular Weight:595.609
Hs Code.:

Synonyms:4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-2-(6-methoxy-5-nitro-quinolin-2-yl)-5,6-dimethyl-nicotinic acid

Suppliers and Price of 4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-2-(6-methoxy-5-nitro-quinolin-2-yl)-5,6-dimethyl-nicotinic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-2-(6-methoxy-5-nitro-quinolin-2-yl)-5,6-dimethyl-nicotinic acid

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-2-(6-methoxy-5-nitro-quinolin-2-yl)-5,6-dimethyl-nicotinic acid

There total 15 articles about 4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-2-(6-methoxy-5-nitro-quinolin-2-yl)-5,6-dimethyl-nicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1-[4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-2-(6-methoxy-5-nitro-quinolin-2-yl)-5,6-dimethyl-pyridin-3-yl]-ethane-1,2-diol

: 77405-74-4
4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-2-(6-methoxy-5-nitro-quinolin-2-yl)-5,6-dimethyl-nicotinic acid

Guidance literature:: With sodium periodate; In 1,4-dioxane; water; at 80 ℃; for 18h;
DOI:10.1021/ja00395a071

Reference yield:

: 42454-06-8
2-nitro-5-hydroxybenzaldehyde

: 77405-74-4
4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-2-(6-methoxy-5-nitro-quinolin-2-yl)-5,6-dimethyl-nicotinic acid

Guidance literature:: Multi-step reaction with 9 steps

1: K₂CO₃, KI / dimethylformamide / 14 h / Ambient temperature

2: benzene / 14 h / Heating

3: Na₂S / methanol / 2 h / Heating

4: 96 percent / t-BuOK / toluene; 2-methyl-propan-2-ol / 10 h / Heating

5: 85 percent / TFA / 1 h / 0 °C

6: HNO₃ / nitromethane / 0.42 h / 5 - 20 °C

7: K₂CO₃ / acetone / 5 h / Heating

8: OsO₄, N-methylmorpholine N-oxide, H₂O / acetone; 2-methyl-propan-2-ol / 20 h / Ambient temperature

9: NaIO₄ / dioxane; H₂O / 18 h / 80 °C

With sodium sulfide; sodium periodate; osmium(VIII) oxide; potassium tert-butylate; water; nitric acid; potassium carbonate; 4-methylmorpholine N-oxide; trifluoroacetic acid; potassium iodide; In 1,4-dioxane; methanol; nitromethane; water; N,N-dimethyl-formamide; acetone; toluene; tert-butyl alcohol; benzene;
DOI:10.1021/ja00395a071

Reference yield:

: 92541-05-4
(Z)-3-Amino-1-(2-benzyloxy-3,4-dimethoxy-phenyl)-2-methyl-but-2-en-1-one

: 77405-74-4
4-(2-Benzyloxy-3,4-dimethoxy-phenyl)-2-(6-methoxy-5-nitro-quinolin-2-yl)-5,6-dimethyl-nicotinic acid

Guidance literature:: Multi-step reaction with 11 steps

1: 97 percent / xylene / 14 h / Heating

2: NaBH₄ / tetrahydrofuran; propan-2-ol / 16 h / Ambient temperature

3: 67 percent / PhPOCl₂ / 3 h / 170 °C

4: 85 percent / dimethylformamide / 14 h / Heating

5: 2.) H₂O, H⁽¹⁺⁾ / 1) C₆H₆, room temperature, 1.5 h

6: 96 percent / t-BuOK / toluene; 2-methyl-propan-2-ol / 10 h / Heating

7: 85 percent / TFA / 1 h / 0 °C

8: HNO₃ / nitromethane / 0.42 h / 5 - 20 °C

9: K₂CO₃ / acetone / 5 h / Heating

10: OsO₄, N-methylmorpholine N-oxide, H₂O / acetone; 2-methyl-propan-2-ol / 20 h / Ambient temperature

11: NaIO₄ / dioxane; H₂O / 18 h / 80 °C

With P,P-dichlorophenylphosphine oxide; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; potassium tert-butylate; water; nitric acid; hydrogen cation; potassium carbonate; 4-methylmorpholine N-oxide; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; nitromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; acetone; toluene; xylene; tert-butyl alcohol;
DOI:10.1021/ja00395a071