(2S,3S)-4-cyclohexyl-3-(dibenzylamino)-1-[(R)-p-tolylsulfinyl]butan-2-ol

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Chemical Name:(2S,3S)-4-cyclohexyl-3-(dibenzylamino)-1-[(R)-p-tolylsulfinyl]butan-2-ol
CAS No.:1279700-04-7
Molecular Formula:C₃₁H₃₉NO₂S
Molecular Weight:489.722
Hs Code.:

Synonyms:(2S,3S)-4-cyclohexyl-3-(dibenzylamino)-1-[(R)-p-tolylsulfinyl]butan-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S)-4-cyclohexyl-3-(dibenzylamino)-1-[(R)-p-tolylsulfinyl]butan-2-ol

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Technology Process of (2S,3S)-4-cyclohexyl-3-(dibenzylamino)-1-[(R)-p-tolylsulfinyl]butan-2-ol

There total 5 articles about (2S,3S)-4-cyclohexyl-3-(dibenzylamino)-1-[(R)-p-tolylsulfinyl]butan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1279699-99-8
(S)-4-cyclohexyl-3-(dibenzylamino)-1-[(R)-p-tolylsulfinyl]butan-2-one

: 1279700-04-7
(2S,3S)-4-cyclohexyl-3-(dibenzylamino)-1-[(R)-p-tolylsulfinyl]butan-2-ol

Guidance literature:: (S)-4-cyclohexyl-3-(dibenzylamino)-1-[(R)-p-tolylsulfinyl]butan-2-one; With diisobutylaluminium hydride; In tetrahydrofuran; toluene; at -78 ℃; for 1.25h; Inert atmosphere;

With methanol; In tetrahydrofuran; toluene; at -78 - 20 ℃; optical yield given as %de; stereoselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.201001403

Reference yield:

: 900535-40-2
methyl 2-bromo-3-cyclohexylpropanoate

: 1279700-04-7
(2S,3S)-4-cyclohexyl-3-(dibenzylamino)-1-[(R)-p-tolylsulfinyl]butan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 0.75 h / -78 °C / Inert atmosphere

2.1: tetrahydrofuran / 240 h / 20 °C / Inert atmosphere

3.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1.25 h / -78 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

With n-butyllithium; diisobutylaluminium hydride; diisopropylamine; In tetrahydrofuran; hexane; toluene;
DOI:10.1002/ejoc.201001403

Reference yield:

: 701-97-3
cyclohexanepropionic acid

: 1279700-04-7
(2S,3S)-4-cyclohexyl-3-(dibenzylamino)-1-[(R)-p-tolylsulfinyl]butan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: bromine; phosphorus tribromide / 20 - 80 °C / Inert atmosphere

1.2: 2 h / Reflux

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: 0.75 h / -78 °C / Inert atmosphere

3.1: tetrahydrofuran / 240 h / 20 °C / Inert atmosphere

4.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1.25 h / -78 °C / Inert atmosphere

4.2: -78 - 20 °C / Inert atmosphere

With n-butyllithium; bromine; phosphorus tribromide; diisobutylaluminium hydride; diisopropylamine; In tetrahydrofuran; hexane; toluene;
DOI:10.1002/ejoc.201001403