Technology Process of FmocNHN((CH2)3NH2)CH2COOBn
There total 3 articles about FmocNHN((CH2)3NH2)CH2COOBn which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Fmoc-aza-β3-Orn(Boc)-Bn;
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
With
sodium carbonate;
In
dichloromethane;
DOI:10.1016/j.bioorg.2010.05.004
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 82 percent / sodium cyanoborohydride; hydrochloric acid / CH2Cl2; methanol / 0.5 h
2: 60 percent / K2CO3 / toluene / 28 h / Heating
3: CF3COOH / CH2Cl2 / 20 °C
With
hydrogenchloride; sodium cyanoborohydride; potassium carbonate; trifluoroacetic acid;
In
methanol; dichloromethane; toluene;
DOI:10.1021/jo051585o
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 60 percent / K2CO3 / toluene / 28 h / Heating
2: CF3COOH / CH2Cl2 / 20 °C
With
potassium carbonate; trifluoroacetic acid;
In
dichloromethane; toluene;
DOI:10.1021/jo051585o
