dimethyl (S)-2-(1-benzylpyrrolidin-2-yl)-2-oxoethylphosphonate

Base Information

• Chemical Name: dimethyl (S)-2-(1-benzylpyrrolidin-2-yl)-2-oxoethylphosphonate
• CAS No.: 1217809-86-3
• Molecular Formula: C₁₅H₂₂NO₄P
• Molecular Weight: 311.318
• Mol file: 1217809-86-3.mol

Synonyms:dimethyl (S)-2-(1-benzylpyrrolidin-2-yl)-2-oxoethylphosphonate

Chemical Property of dimethyl (S)-2-(1-benzylpyrrolidin-2-yl)-2-oxoethylphosphonate

Chemical Property:

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Technology Process of dimethyl (S)-2-(1-benzylpyrrolidin-2-yl)-2-oxoethylphosphonate

There total 1 articles about dimethyl (S)-2-(1-benzylpyrrolidin-2-yl)-2-oxoethylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

(S)-N-benzyl-O-benzylpyrrolidine-2-carboxylate (83528-04-5) + dimethyl methane phosphonate (756-79-6) → dimethyl (S)-2-(1-benzylpyrrolidin-2-yl)-2-oxoethylphosphonate (1217809-86-3)

Guidance literature:

dimethyl methane phosphonate; With n-butyllithium; In tetrahydrofuran; hexane; at -78 - -50 ℃;

(S)-N-benzyl-O-benzylpyrrolidine-2-carboxylate; In tetrahydrofuran; hexane; at -78 ℃; for 4h;

DOI:10.3390/molecules15031291

Reference yield: 78.0%

dimethyl (S)-2-(1-benzylpyrrolidin-2-yl)-2-oxoethylphosphonate (1217809-86-3) → C15H24NO4P (1217809-92-1)

Guidance literature:

dimethyl (S)-2-(1-benzylpyrrolidin-2-yl)-2-oxoethylphosphonate; With benzo[1,3,2]dioxaborole; In tetrahydrofuran; at -78 ℃; for 5h;

With water; ammonium chloride; In tetrahydrofuran; optical yield given as %de; diastereoselective reaction;

DOI:10.3390/molecules15031291

Reference yield:

dimethyl (S)-2-(1-benzylpyrrolidin-2-yl)-2-oxoethylphosphonate (1217809-86-3) → C15H24NO4P + C15H24NO4P (1217809-92-1)

Guidance literature:

dimethyl (S)-2-(1-benzylpyrrolidin-2-yl)-2-oxoethylphosphonate; With diisobutylaluminium hydride; In tetrahydrofuran; at -78 ℃; for 5h;

With water; ammonium chloride; In tetrahydrofuran; optical yield given as %de; diastereoselective reaction;

DOI:10.3390/molecules15031291

upstream raw materials:

(S)-N-benzyl-O-benzylpyrrolidine-2-carboxylate

dimethyl methane phosphonate

Downstream raw materials:

C₁₅H₂₄NO₄P