4-[2-(3-{4-[1-(4-isobutyl-phenyl)-ethoxy]-2,3-dimethyl-phenyl}-[1,2,4]oxadiazol-5-yl)-phenoxy]-butyric acid ethyl ester

Base Information

• Chemical Name: 4-[2-(3-{4-[1-(4-isobutyl-phenyl)-ethoxy]-2,3-dimethyl-phenyl}-[1,2,4]oxadiazol-5-yl)-phenoxy]-butyric acid ethyl ester
• CAS No.: 448961-63-5
• Molecular Formula: C₃₄H₄₀N₂O₅
• Molecular Weight: 556.702
• Mol file: 448961-63-5.mol

Synonyms:4-[2-(3-{4-[1-(4-isobutyl-phenyl)-ethoxy]-2,3-dimethyl-phenyl}-[1,2,4]oxadiazol-5-yl)-phenoxy]-butyric acid ethyl ester

Chemical Property of 4-[2-(3-{4-[1-(4-isobutyl-phenyl)-ethoxy]-2,3-dimethyl-phenyl}-[1,2,4]oxadiazol-5-yl)-phenoxy]-butyric acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[2-(3-{4-[1-(4-isobutyl-phenyl)-ethoxy]-2,3-dimethyl-phenyl}-[1,2,4]oxadiazol-5-yl)-phenoxy]-butyric acid ethyl ester

There total 7 articles about 4-[2-(3-{4-[1-(4-isobutyl-phenyl)-ethoxy]-2,3-dimethyl-phenyl}-[1,2,4]oxadiazol-5-yl)-phenoxy]-butyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.0%

2-(3-ethoxycarbonylpropoxy)benzoic acid methyl ester (448961-62-4) + 4-[1-(4-isobutylphenyl)ethoxy]-2,3-dimethylbenzamidoxime (448961-61-3) → 4-[3-(3-{4-[1-(4-isobutyl-phenyl)-ethoxy]-2,3-dimethyl-phenyl}-[1,2,4]oxadiazol-5-yl)-propoxy]-benzoic acid methyl ester + 4-[3-(3-{4-[1-(4-isobutyl-phenyl)-ethoxy]-2,3-dimethyl-phenyl}-[1,2,4]oxadiazol-5-yl)-propoxy]-benzoic acid ethyl ester + 4-[2-(3-{4-[1-(4-isobutyl-phenyl)-ethoxy]-2,3-dimethyl-phenyl}-[1,2,4]oxadiazol-5-yl)-phenoxy]-butyric acid ethyl ester (448961-63-5)

Guidance literature:

4-[1-(4-isobutylphenyl)ethoxy]-2,3-dimethylbenzamidoxime; With 4 A molecular sieve; sodium hydride; In tetrahydrofuran; at 60 ℃; for 0.0166667h;

2-(3-ethoxycarbonylpropoxy)benzoic acid methyl ester; In tetrahydrofuran; at 60 ℃; for 3h;

DOI:10.1002/jccs.200200014

Reference yield:

Ethyl 4-bromobutyrate (2969-81-5) → 4-[2-(3-{4-[1-(4-isobutyl-phenyl)-ethoxy]-2,3-dimethyl-phenyl}-[1,2,4]oxadiazol-5-yl)-phenoxy]-butyric acid ethyl ester (448961-63-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 98 percent / K₂CO₃ / acetonitrile / 24 h / Heating

2.1: 4A molecular sieves; NaH / tetrahydrofuran / 0.02 h / 60 °C

2.2: 9 percent / tetrahydrofuran / 3 h / 60 °C

With 4 A molecular sieve; sodium hydride; potassium carbonate; In tetrahydrofuran; acetonitrile;

DOI:10.1002/jccs.200200014

Reference yield:

2,3-dimethyl-4-methoxybenzaldehyde (38998-17-3) → 4-[2-(3-{4-[1-(4-isobutyl-phenyl)-ethoxy]-2,3-dimethyl-phenyl}-[1,2,4]oxadiazol-5-yl)-phenoxy]-butyric acid ethyl ester (448961-63-5)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 96 percent / aq. hydroxylamine-sulfonic acid / acetonitrile / 18 h / 60 °C

2.1: 98 percent / BBr₃ / CH₂Cl₂ / 6 h / 50 °C

3.1: 49 percent / Ph₃P; DEAD / tetrahydrofuran / 8 h / 20 °C

4.1: 45 percent / hydroxylamine hydrochloride; Et₃N / ethanol / 192 h / Heating

5.1: 4A molecular sieves; NaH / tetrahydrofuran / 0.02 h / 60 °C

5.2: 9 percent / tetrahydrofuran / 3 h / 60 °C

With (hydroxylamino)sulfonic acid; 4 A molecular sieve; hydroxylamine hydrochloride; boron tribromide; sodium hydride; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile; 3.1: Mitsunobu reaction;

DOI:10.1002/jccs.200200014

upstream raw materials:

2-(3-ethoxycarbonylpropoxy)benzoic acid methyl ester

4-[1-(4-isobutylphenyl)ethoxy]-2,3-dimethylbenzamidoxime

Ethyl 4-bromobutyrate

2,3-dimethyl-4-methoxybenzaldehyde