Methyl 2,3-dihydro-5-hydroxy-2-(phenylmethyl)-2-benzofurancarboxylate

Base Information

Chemical Name:Methyl 2,3-dihydro-5-hydroxy-2-(phenylmethyl)-2-benzofurancarboxylate
CAS No.:863970-63-2
Molecular Formula:C₁₇H₁₆O₄
Molecular Weight:284.312
Hs Code.:
DSSTox Substance ID:DTXSID601155630

Synonyms:DTXSID601155630;Methyl 2,3-dihydro-5-hydroxy-2-(phenylmethyl)-2-benzofurancarboxylate;863970-63-2

Suppliers and Price of Methyl 2,3-dihydro-5-hydroxy-2-(phenylmethyl)-2-benzofurancarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Methyl 2,3-dihydro-5-hydroxy-2-(phenylmethyl)-2-benzofurancarboxylate

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:284.10485899
Heavy Atom Count:21
Complexity:377

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C1(CC2=C(O1)C=CC(=C2)O)CC3=CC=CC=C3

Technology Process of Methyl 2,3-dihydro-5-hydroxy-2-(phenylmethyl)-2-benzofurancarboxylate

There total 3 articles about Methyl 2,3-dihydro-5-hydroxy-2-(phenylmethyl)-2-benzofurancarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-benzyl-5-methoxy-2,3-dihydro-benzofuran-2-carboxylic acid methyl ester

: 863970-63-2
methyl 2-benzyl-5-hydroxy-2,3-dihydro-1-benzofuran-2-carboxylate

Guidance literature:: With boron tribromide; In dichloromethane; at 0 ℃;
DOI:10.1021/jm050373g

Reference yield:

: 1751-24-2
5-methoxy-benzofuran-2-carboxylic acid methyl ester

: 863970-63-2
methyl 2-benzyl-5-hydroxy-2,3-dihydro-1-benzofuran-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1.3 g / H₂ / Pd/C / ethanol / 72 h / 2327.17 Torr

2.1: HMPA; lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C

2.2: tetrahydrofuran / -78 - 25 °C

3.1: BBr₃ / CH₂Cl₂ / 0 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; hydrogen; boron tribromide; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm050373g

Reference yield:

: 653578-12-2
methyl 5-methoxy-2,3-dihydro-1-benzofuran-2-carboxylate

: 863970-63-2
methyl 2-benzyl-5-hydroxy-2,3-dihydro-1-benzofuran-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: HMPA; lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C

1.2: tetrahydrofuran / -78 - 25 °C

2.1: BBr₃ / CH₂Cl₂ / 0 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; boron tribromide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm050373g