Tenamfetamine

Base Information

• Chemical Name: Tenamfetamine
• CAS No.: 4764-17-4
• Deprecated CAS: 51497-09-7
• Molecular Formula: C10H13NO2
• Molecular Weight: 179.219
• European Community (EC) Number: 803-951-7
• UNII: XJZ28FJ27W
• DSSTox Substance ID: DTXSID40859958
• Nikkaji Number: J1.191.661I,J1.191.662G,J40.084J
• Wikipedia: 3,4-Methylenedioxyamphetamine
• Wikidata: Q223020
• NCI Thesaurus Code: C80152
• Pharos Ligand ID: W94AR2N82Q8D
• Metabolomics Workbench ID: 49636
• ChEMBL ID: CHEMBL6731
• Mol file: 4764-17-4.mol

Synonyms:3,4 Methylenedioxyamphetamine;3,4-Methylenedioxyamphetamine

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Tenamfetamine

Chemical Property:

• Vapor Pressure: 0.0035mmHg at 25°C
• Melting Point: 178-179 °C
• Refractive Index: 1.5150 (estimate)
• Boiling Point: 281.7°C at 760 mmHg
• PKA: 9.94±0.10(Predicted)
• Flash Point: 134.9°C
• PSA: 44.48000
• Density: 1.163g/cm³
• LogP: 2.00530
• Storage Temp.: 2-8°C
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 179.094628657
• Heavy Atom Count: 13
• Complexity: 174

Purity/Quality:

Safty Information:

• Hazard Codes: F,T
• Statements: 11-23/24/25-39/23/24/25
• Safety Statements: 16-36/37-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CC1=CC2=C(C=C1)OCO2)N
• Recent ClinicalTrials: Effects of MDMA-like Substances in Healthy Subjects
• Uses: A metabolite of MDMA. Entactogen; synthetic amphetamine derivative with stimulant and hallucinogenic properties. Controlled substance (hallucinogen).

Technology Process of Tenamfetamine

There total 32 articles about Tenamfetamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

5-(2-nitroprop-1-enyl)benzo[d][1,3]dioxole (5438-41-5) → 3,4-methylenedioxyamphetamine (4764-17-4)

Guidance literature:

With lithium aluminium tetrahydride;

DOI:10.1002/jps.2600690220

Reference yield: 70.0%

1-(1,3-benzodioxol-5-yl)-2-propanone (4676-39-5) + ammonium acetate (631-61-8,92206-38-7) → 3,4-methylenedioxyamphetamine (4764-17-4)

Guidance literature:

With hydrogenchloride; sodium cyanoborohydride; In methanol; at 20 ℃; for 24h;

DOI:10.1002/adsc.202100351

Reference yield: 31.0%

1-(1,3-benzodioxol-5-yl)-2-propanone (4676-39-5) → 3,4-methylenedioxyamphetamine (4764-17-4)

Guidance literature:

With ammonia; sodium cyanoborohydride;

upstream raw materials:

1-allyl-3,4-methylenedioxybenzene

1-(1,3-benzodioxol-5-yl)-2-propanone

formamide

benzo[1,3]dioxol-5-yl-acetone oxime

Downstream raw materials:

quinoline-2-carboxylic acid-(2-benzo[1,3]dioxol-5-yl-1-methyl-ethylamide)

(3,4-dimethoxy-phenyl)-acetic acid-(2-benzo[1,3]dioxol-5-yl-1-methyl-ethylamide)

7-methyl-5,6,7,8-tetrahydro-1,3-dioxolo[4,5-g]isoquinoline

N-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline

Refernces

• 1、 González-Martínez, Daniel,Gotor, Vicente,Gotor-Fernández, Vicente. "Stereoselective Synthesis of 1-Arylpropan-2-amines from Allylbenzenes through a Wacker-Tsuji Oxidation-Biotransamination Sequential Process". . p. 2582 - 2593. Retrieved 2019/05/15.
• 2、 Keizers, Peter H. J.,De Graaf, Chris,De Kanter, Frans J. J.,Oostenbrink, Chris,Feenstra, K. Anton,Commandeur, Jan N. M.,Vermeulen, Nico P. E.. "Metabolic regio- and stereoselectivity of cytochrome P450 2D6 towards 3,4-methylenedioxy-N-alkylamphetamines: In silico predictions and experimental validation". . p. 6117 - 6127. Retrieved 2007/10/03.