4-nitrobenzyl (2R,5R,6R)-3,7-dioxo-6-(1-methoxy-1-methylethyl)-1-azabicyclo<3.2.0>heptane-2-carboxylate

Base Information

Chemical Name:4-nitrobenzyl (2R,5R,6R)-3,7-dioxo-6-(1-methoxy-1-methylethyl)-1-azabicyclo<3.2.0>heptane-2-carboxylate
CAS No.:89063-94-5
Molecular Formula:C₁₈H₂₀N₂O₇
Molecular Weight:376.366
Hs Code.:

Synonyms:4-nitrobenzyl (2R,5R,6R)-3,7-dioxo-6-(1-methoxy-1-methylethyl)-1-azabicyclo<3.2.0>heptane-2-carboxylate

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Chemical Property of 4-nitrobenzyl (2R,5R,6R)-3,7-dioxo-6-(1-methoxy-1-methylethyl)-1-azabicyclo<3.2.0>heptane-2-carboxylate

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Technology Process of 4-nitrobenzyl (2R,5R,6R)-3,7-dioxo-6-(1-methoxy-1-methylethyl)-1-azabicyclo<3.2.0>heptane-2-carboxylate

There total 6 articles about 4-nitrobenzyl (2R,5R,6R)-3,7-dioxo-6-(1-methoxy-1-methylethyl)-1-azabicyclo<3.2.0>heptane-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 89063-93-4
4-nitrobenzyl (2R,3R)-2-diazo-4-<3-(1-methoxy-1-methylethyl)-4-oxoazetidin-2-yl>-3-oxobutanoate

: 89063-94-5
4-nitrobenzyl (2R,5R,6R)-3,7-dioxo-6-(1-methoxy-1-methylethyl)-1-azabicyclo<3.2.0>heptane-2-carboxylate

Guidance literature:: With dirhodium tetraacetate; In benzene; for 30h; Heating;

Reference yield:

: 86541-17-5
(6R)-2,2-dimethyl-3-oxa-1-azabicyclo<4.2.0>octan-8-one

: 89063-94-5
4-nitrobenzyl (2R,5R,6R)-3,7-dioxo-6-(1-methoxy-1-methylethyl)-1-azabicyclo<3.2.0>heptane-2-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) n-BuLi, 3.) Ph₃SnH, 4.) HMPA

2: 95 percent / AcOH, H₂O / 0.5 h / 65 °C

3: 79 percent / Jones reagent / acetone / 40 h / Ambient temperature

4: 1.) N,N'-carbonyldiimidazole / 1.) THF, RT, 5 h, 2.) THF, RT, overnight

5: 1.) p-toluenesulfonyl azide, 2.) Et₃N / 1.) MeCN, 0 deg C, 10 min, 2.) MeCN, 0 deg C, 50 min

6: 100 percent / Rh₂(AcO)4 / benzene / 30 h / Heating

With N,N,N,N,N,N-hexamethylphosphoric triamide; dirhodium tetraacetate; n-butyllithium; 4-toluenesulfonyl azide; jones reagent; triphenylstannane; water; acetic acid; triethylamine; 1,1'-carbonyldiimidazole; In acetone; benzene;

Reference yield:

: (3R,4S)-4-(2-hydroxyethyl)-3-(1-methoxy-1-methylethyl)azetidin-2-one

: 89063-94-5
4-nitrobenzyl (2R,5R,6R)-3,7-dioxo-6-(1-methoxy-1-methylethyl)-1-azabicyclo<3.2.0>heptane-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 79 percent / Jones reagent / acetone / 40 h / Ambient temperature

2: 1.) N,N'-carbonyldiimidazole / 1.) THF, RT, 5 h, 2.) THF, RT, overnight

3: 1.) p-toluenesulfonyl azide, 2.) Et₃N / 1.) MeCN, 0 deg C, 10 min, 2.) MeCN, 0 deg C, 50 min

4: 100 percent / Rh₂(AcO)4 / benzene / 30 h / Heating

With dirhodium tetraacetate; 4-toluenesulfonyl azide; jones reagent; triethylamine; 1,1'-carbonyldiimidazole; In acetone; benzene;