tert-butyl (2R,3S)-2-hydroxy-3-{N-benzyl-N-[(R)-α-methylbenzyl]amino}-4,4-diethoxybutanoate

Base Information

Chemical Name:tert-butyl (2R,3S)-2-hydroxy-3-{N-benzyl-N-[(R)-α-methylbenzyl]amino}-4,4-diethoxybutanoate
CAS No.:1606140-44-6
Molecular Formula:C₂₇H₃₉NO₅
Molecular Weight:457.61
Hs Code.:

Synonyms:tert-butyl (2R,3S)-2-hydroxy-3-{N-benzyl-N-[(R)-α-methylbenzyl]amino}-4,4-diethoxybutanoate

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Chemical Property of tert-butyl (2R,3S)-2-hydroxy-3-{N-benzyl-N-[(R)-α-methylbenzyl]amino}-4,4-diethoxybutanoate

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Technology Process of tert-butyl (2R,3S)-2-hydroxy-3-{N-benzyl-N-[(R)-α-methylbenzyl]amino}-4,4-diethoxybutanoate

There total 5 articles about tert-butyl (2R,3S)-2-hydroxy-3-{N-benzyl-N-[(R)-α-methylbenzyl]amino}-4,4-diethoxybutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 1606140-38-8
tert-butyl (E)-4,4-diethoxybut-2-enoate

: 38235-77-7
(R)-N-benzyl-1-phenylethylamine

: 1606140-44-6
tert-butyl (2R,3S)-2-hydroxy-3-{N-benzyl-N-[(R)-α-methylbenzyl]amino}-4,4-diethoxybutanoate

Guidance literature:: (R)-N-benzyl-1-phenylethylamine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

tert-butyl (E)-4,4-diethoxybut-2-enoate; In tetrahydrofuran; hexane; at -78 ℃; for 2h; Inert atmosphere;

With (1R)-(-)-(10-camphorsulfonyl)oxaziridine; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 12h; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2014.03.055

Reference yield:

: 1613225-08-3
C₂₇H₃₇NO₅

: 1606140-67-3
tert-butyl (2S,3S)-2-hydroxy-3-{N-benzyl-N-[(R)-α-methylbenzyl]amino}-4,4-diethoxybutanoate

: 1606140-44-6
tert-butyl (2R,3S)-2-hydroxy-3-{N-benzyl-N-[(R)-α-methylbenzyl]amino}-4,4-diethoxybutanoate

Guidance literature:: With sodium tetrahydroborate; In methanol; at -20 - 20 ℃; Reagent/catalyst; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2014.03.055

Reference yield:

: 1613225-08-3
C₂₇H₃₇NO₅

: 1606140-44-6
tert-butyl (2R,3S)-2-hydroxy-3-{N-benzyl-N-[(R)-α-methylbenzyl]amino}-4,4-diethoxybutanoate

Guidance literature:: With lithium borohydride; In methanol; at -20 ℃; Reagent/catalyst; diastereoselective reaction; Inert atmosphere;
DOI:10.1016/j.tet.2014.03.055