N-(7-{3-[2-(4-fluorophenyl)ethyl]-4-hydroxyphenoxy}-6-methylindan-4-yl)malonamic acid

Base Information

Chemical Name:N-(7-{3-[2-(4-fluorophenyl)ethyl]-4-hydroxyphenoxy}-6-methylindan-4-yl)malonamic acid
CAS No.:575503-96-7
Molecular Formula:C₂₇H₂₆FNO₅
Molecular Weight:463.506
Hs Code.:

Synonyms:N-(7-{3-[2-(4-fluorophenyl)ethyl]-4-hydroxyphenoxy}-6-methylindan-4-yl)malonamic acid

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Chemical Property of N-(7-{3-[2-(4-fluorophenyl)ethyl]-4-hydroxyphenoxy}-6-methylindan-4-yl)malonamic acid

Chemical Property:

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Technology Process of N-(7-{3-[2-(4-fluorophenyl)ethyl]-4-hydroxyphenoxy}-6-methylindan-4-yl)malonamic acid

There total 5 articles about N-(7-{3-[2-(4-fluorophenyl)ethyl]-4-hydroxyphenoxy}-6-methylindan-4-yl)malonamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 575503-56-9
ethyl N-(7-{3-[2-(4-fluorophenyl)ethyl]-4-hydroxyphenoxy}-6-methylindan-4-yl)malonamate

: 575503-96-7
N-(7-{3-[2-(4-fluorophenyl)ethyl]-4-hydroxyphenoxy}-6-methylindan-4-yl)malonamic acid

Guidance literature:: With water; sodium hydroxide; In methanol; at 60 ℃; for 0.5h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.12.002

Reference yield:

: 575505-01-0
[7-(4-methoxyphenoxy)-6-methylindan-4-yl]amine

: 575503-96-7
N-(7-{3-[2-(4-fluorophenyl)ethyl]-4-hydroxyphenoxy}-6-methylindan-4-yl)malonamic acid

Guidance literature:: Multi-step reaction with 5 steps

1: pyridine / dichloromethane / 3 h / 20 °C

2: trifluoromethylsulfonic anhydride / dichloromethane / 15 h / 20 °C

3: boron trichloride / dichloromethane / 72 h / 0 - 20 °C

4: triethylsilane; trifluoroacetic acid / dichloromethane / 20 °C

5: water; sodium hydroxide / methanol / 0.5 h / 60 °C / Inert atmosphere

With pyridine; triethylsilane; trifluoromethylsulfonic anhydride; water; boron trichloride; trifluoroacetic acid; sodium hydroxide; In methanol; dichloromethane; 2: |Friedel-Crafts Acylation;
DOI:10.1016/j.bmc.2012.12.002

Reference yield:

: 575504-26-6
5-methyl-7-nitroindan-4-ol

: 575503-96-7
N-(7-{3-[2-(4-fluorophenyl)ethyl]-4-hydroxyphenoxy}-6-methylindan-4-yl)malonamic acid

Guidance literature:: Multi-step reaction with 7 steps

1: copper; triethylamine / dichloromethane / 120 h / 20 °C

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 20 °C

3: pyridine / dichloromethane / 3 h / 20 °C

4: trifluoromethylsulfonic anhydride / dichloromethane / 15 h / 20 °C

5: boron trichloride / dichloromethane / 72 h / 0 - 20 °C

6: triethylsilane; trifluoroacetic acid / dichloromethane / 20 °C

7: water; sodium hydroxide / methanol / 0.5 h / 60 °C / Inert atmosphere

With pyridine; triethylsilane; trifluoromethylsulfonic anhydride; palladium 10% on activated carbon; water; hydrogen; boron trichloride; copper; triethylamine; trifluoroacetic acid; sodium hydroxide; In methanol; dichloromethane; ethyl acetate; 4: |Friedel-Crafts Acylation;
DOI:10.1016/j.bmc.2012.12.002