2-[(2-chloro-1-oxo-3-methylbutyl)-amino]-β-oxo-N-(2-thiazolyl)-(3-trifluoromethyl)-benzene-propanamide

Base Information

Chemical Name:2-[(2-chloro-1-oxo-3-methylbutyl)-amino]-β-oxo-N-(2-thiazolyl)-(3-trifluoromethyl)-benzene-propanamide
CAS No.:114377-09-2
Molecular Formula:C₁₈H₁₇ClF₃N₃O₃S
Molecular Weight:447.865
Hs Code.:

Synonyms:2-[(2-chloro-1-oxo-3-methylbutyl)-amino]-β-oxo-N-(2-thiazolyl)-(3-trifluoromethyl)-benzene-propanamide

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Chemical Property of 2-[(2-chloro-1-oxo-3-methylbutyl)-amino]-β-oxo-N-(2-thiazolyl)-(3-trifluoromethyl)-benzene-propanamide

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Technology Process of 2-[(2-chloro-1-oxo-3-methylbutyl)-amino]-β-oxo-N-(2-thiazolyl)-(3-trifluoromethyl)-benzene-propanamide

There total 4 articles about 2-[(2-chloro-1-oxo-3-methylbutyl)-amino]-β-oxo-N-(2-thiazolyl)-(3-trifluoromethyl)-benzene-propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 97817-20-4
ethyl 2-[(2-chloro-1-oxo-3-methylbutyl)-amino]-β-oxo-α-[(2-thiazolylamino)-carbonyl]-3-trifluoromethyl-benzene-propanoate

: 114377-09-2
2-[(2-chloro-1-oxo-3-methylbutyl)-amino]-β-oxo-N-(2-thiazolyl)-(3-trifluoromethyl)-benzene-propanamide

Guidance literature:: With sulfuric acid; acetic acid; In water; acetone;

Reference yield:

: 921-08-4
2-chloro-3-methylbutanoic acid

: 114377-09-2
2-[(2-chloro-1-oxo-3-methylbutyl)-amino]-β-oxo-N-(2-thiazolyl)-(3-trifluoromethyl)-benzene-propanamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-methylmorpholine, isobutyl chloroformate / CH₂Cl₂ / 0.5 h / -20 °C

2: 78 percent / N-methylmorpholine / CH₂Cl₂ / 20 h / Ambient temperature

3: 1.) butyllithium / 1) THF, 0 deg C; 2) -75 deg C, THF

With 4-methyl-morpholine; n-butyllithium; isobutyl chloroformate; In dichloromethane;
DOI:10.1021/jm00402a034

Reference yield:

: 35383-59-6
2-chloro-3-methylbutanoyl chloride

: 114377-09-2
2-[(2-chloro-1-oxo-3-methylbutyl)-amino]-β-oxo-N-(2-thiazolyl)-(3-trifluoromethyl)-benzene-propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / N-methylmorpholine / CH₂Cl₂ / 20 h / Ambient temperature

2: 1.) butyllithium / 1) THF, 0 deg C; 2) -75 deg C, THF

With 4-methyl-morpholine; n-butyllithium; In dichloromethane;
DOI:10.1021/jm00402a034