amino-(3,4-dimethoxyphenyl)methane phosphonic acid

Base Information

• Chemical Name: amino-(3,4-dimethoxyphenyl)methane phosphonic acid
• CAS No.: 107395-15-3
• Molecular Formula: C₉H₁₄NO₅P
• Molecular Weight: 247.188
• Mol file: 107395-15-3.mol

Synonyms:amino-(3,4-dimethoxyphenyl)methane phosphonic acid

Chemical Property of amino-(3,4-dimethoxyphenyl)methane phosphonic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of amino-(3,4-dimethoxyphenyl)methane phosphonic acid

There total 4 articles about amino-(3,4-dimethoxyphenyl)methane phosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.9%

[Amino-(3,4-dimethoxy-phenyl)-methyl]-phosphonic acid diethyl ester (135473-62-0) → amino-(3,4-dimethoxyphenyl)methane phosphonic acid (107395-15-3)

Guidance literature:

With hydrogenchloride; for 5h; Heating;

Reference yield:

3,4-dimethoxy-benzaldehyde (120-14-9) → amino-(3,4-dimethoxyphenyl)methane phosphonic acid (107395-15-3)

Guidance literature:

3,4-dimethoxy-benzaldehyde; With acetamide; acetyl chloride; In acetic acid; at 0 - 20 ℃; for 4.5h;

With phosphorus trichloride; In acetic acid; for 2h; Heating;

With hydrogenchloride; for 6h;

DOI:10.1039/b401633e

Reference yield:

benzyl-veratryliden-amine (33859-00-6) → amino-(3,4-dimethoxyphenyl)methane phosphonic acid (107395-15-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 89.5 percent / BF₃*Et₂O / diethyl ether / 14 h / 20 °C

2: 68.2 percent / H₂ / 5percent Pd/C / ethanol / 30 h / 20 - 25 °C / 760 Torr

3: 78.9 percent / 20percent HCl / 5 h / Heating

With hydrogenchloride; boron trifluoride diethyl etherate; hydrogen; palladium on activated charcoal; In diethyl ether; ethanol;

upstream raw materials:

[Amino-(3,4-dimethoxy-phenyl)-methyl]-phosphonic acid diethyl ester

3,4-dimethoxy-benzaldehyde

benzyl-veratryliden-amine

[Benzylamino-(3,4-dimethoxy-phenyl)-methyl]-phosphonic acid diethyl ester

Downstream raw materials:

1-Amino-1-(3',4'-dihydroxyphenyl)methylphosphonic acid

3,4-dihydroxybenzaldehyde