Technology Process of 1-methyl(diphenyl)silyl-2-phenyl-3-trimethylsilyl-5-iodobenzene
There total 4 articles about 1-methyl(diphenyl)silyl-2-phenyl-3-trimethylsilyl-5-iodobenzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Iodine monochloride;
In
dichloromethane;
at 0 - 20 ℃;
for 16h;
Inert atmosphere;
DOI:10.1021/ol4010883
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium / hexane; tetrahydrofuran / 0.5 h / -78 - 0 °C / Inert atmosphere
1.2: -78 - 20 °C / Inert atmosphere
2.1: diisobutylaluminium hydride / hexane; tetrahydrofuran / 0 - 50 °C / Inert atmosphere
2.2: 3 h / 0 - 20 °C / Inert atmosphere
3.1: palladium diacetate; N-ethyl-N,N-diisopropylamine / 24 h / 30 °C / Inert atmosphere
4.1: Iodine monochloride / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere
With
n-butyllithium; palladium diacetate; Iodine monochloride; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/ol4010883
- Guidance literature:
-
Multi-step reaction with 2 steps
1: palladium diacetate; N-ethyl-N,N-diisopropylamine / 24 h / 30 °C / Inert atmosphere
2: Iodine monochloride / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere
With
palladium diacetate; Iodine monochloride; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
DOI:10.1021/ol4010883
