8-Amino-3-D-ribofuranosyl-1,2,4-triazolo(4,3-a)pyrazine

Base Information

Chemical Name:8-Amino-3-D-ribofuranosyl-1,2,4-triazolo(4,3-a)pyrazine
CAS No.:68797-11-5
Molecular Formula:C10H13N5O4
Molecular Weight:267.24
Hs Code.:
DSSTox Substance ID:DTXSID30988504
Mol file:68797-11-5.mol

Synonyms:8-amino-3-D-ribofuranosyl-1,2,4-triazolo(4,3-a)pyrazine;8-ARTP

Suppliers and Price of 8-Amino-3-D-ribofuranosyl-1,2,4-triazolo(4,3-a)pyrazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 8-Amino-3-D-ribofuranosyl-1,2,4-triazolo(4,3-a)pyrazine

Chemical Property:

PSA：139.02000
Density:2.08g/cm³
LogP:-1.55830
XLogP3:-2
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:2
Exact Mass:267.09675391
Heavy Atom Count:19
Complexity:335

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CN2C(=NN=C2C(=N1)N)C3C(C(C(O3)CO)O)O
Isomeric SMILES:C1=CN2C(=NN=C2C(=N1)N)C3[C@@H]([C@@H]([C@H](O3)CO)O)O

Technology Process of 8-Amino-3-D-ribofuranosyl-1,2,4-triazolo(4,3-a)pyrazine

There total 3 articles about 8-Amino-3-D-ribofuranosyl-1,2,4-triazolo(4,3-a)pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 89578-31-4
8-(benzylthio)-3-(2',3',5'-tri-O-benzoyl-β-D-ribofuranosyl)-1,2,4-triazolo<4,3-a>pyrazine

: 68797-11-5
8-amino-3-β-D-ribofuranosyl-1,2,4-triazolo<4,3-a>pyrazine

Guidance literature:: With ammonia; In methanol; at 100 - 110 ℃; for 72h;
DOI:10.1021/jm00373a020

Reference yield:

: 38716-29-9
benzyl 2,5-anhydro-3,4,6-tri-O-benzoyl-D-allonothioimidate hydrochloride

: 68797-11-5
8-amino-3-β-D-ribofuranosyl-1,2,4-triazolo<4,3-a>pyrazine

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 1.) RT, 3 h, 2.) reflux, 1.5 h

2: 64 percent / NH₃ (gas) / methanol / 72 h / 100 - 110 °C

With pyridine; ammonia; In methanol;
DOI:10.1021/jm00373a020

Reference yield:

: 68797-11-5
8-amino-3-β-D-ribofuranosyl-1,2,4-triazolo<4,3-a>pyrazine

Guidance literature:: 3-(5'-O-Benzoyl-2',3'-di-O-acetyl-β-D-ribofuranosyl)-8-chlor-s-triazolo<4,3-a>pyrazin (29), MeOH/NH3;
DOI:10.1021/jo01321a002