rac-3-(3-pyridine)propionic acid 1-phenyl-ethyl ester

Base Information

• Chemical Name: rac-3-(3-pyridine)propionic acid 1-phenyl-ethyl ester
• CAS No.: 934631-20-6
• Molecular Formula: C₁₆H₁₇NO₂
• Molecular Weight: 255.316
• Mol file: 934631-20-6.mol

Synonyms:rac-3-(3-pyridine)propionic acid 1-phenyl-ethyl ester

Chemical Property of rac-3-(3-pyridine)propionic acid 1-phenyl-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of rac-3-(3-pyridine)propionic acid 1-phenyl-ethyl ester

There total 2 articles about rac-3-(3-pyridine)propionic acid 1-phenyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3-pyridine propionic acid (3724-19-4) + 1-Phenylethanol (98-85-1,13323-81-4) → rac-3-(3-pyridine)propionic acid 1-phenyl-ethyl ester (934631-20-6)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 20 ℃; for 48h;

DOI:10.1002/adsc.200606040

Reference yield:

3-(3-pyridyl)propan-1-ol (2859-67-8) → rac-3-(3-pyridine)propionic acid 1-phenyl-ethyl ester (934631-20-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / KMnO₄; aq. H₂SO₄ / 24 h / 20 °C

2: 87 percent / N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride; Et₃N; 4-(dimethylamino)-pyridine / CH₂Cl₂ / 48 h / 20 °C

With dmap; potassium permanganate; sulfuric acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane;

DOI:10.1002/adsc.200606040

Reference yield:

rac-3-(3-pyridine)propionic acid 1-phenyl-ethyl ester (934631-20-6) → 3-(3-pyridine)propionic acid (S)-1-phenyl-ethyl ester + 3-(3-pyridine)propionic acid (R)-1-phenyl-ethyl ester + (S)-1-phenylethanol (1445-91-6) + (R)-1-phenylethanol (1517-69-7)

Guidance literature:

With BES buffer; subtilisin Carlsberg (EC 3.4.21.62); In acetonitrile; at 30 ℃; for 6h; pH=7.2; Further Variations:; Reagents; Product distribution;

DOI:10.1002/adsc.200606040

upstream raw materials:

3-pyridine propionic acid

1-Phenylethanol

3-(3-pyridyl)propan-1-ol

Downstream raw materials:

(S)-1-phenylethanol

(R)-1-phenylethanol