N₂-[1-(5-fluoropyrimidin-2-yl)ethyl]-N₄-(1-methyl-1H-imidazol-4-yl)-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

Base Information

• Chemical Name: N₂-[1-(5-fluoropyrimidin-2-yl)ethyl]-N₄-(1-methyl-1H-imidazol-4-yl)-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine
• CAS No.: 1220516-46-0
• Molecular Formula: C₂₃H₂₂FN₉O₂S
• Molecular Weight: 507.551

Synonyms:N₂-[1-(5-fluoropyrimidin-2-yl)ethyl]-N₄-(1-methyl-1H-imidazol-4-yl)-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

Chemical Property of N₂-[1-(5-fluoropyrimidin-2-yl)ethyl]-N₄-(1-methyl-1H-imidazol-4-yl)-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

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Technology Process of N₂-[1-(5-fluoropyrimidin-2-yl)ethyl]-N₄-(1-methyl-1H-imidazol-4-yl)-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine

There total 1 articles about N₂-[1-(5-fluoropyrimidin-2-yl)ethyl]-N₄-(1-methyl-1H-imidazol-4-yl)-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1S)-1-(5-fluoropyrimidin-2-yl)ethanamine monohydrochloride (935667-21-3) + 2-chloro-N-(1-methyl-1H-imidazol-4-yl)-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine (1220517-76-9) → N2-[1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(1-methyl-1H-imidazol-4-yl)-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine (1220516-46-0)

Guidance literature:

With caesium carbonate; (R)-1-[(S_P)-2-(dicyclohexylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; palladium diacetate; In N,N-dimethyl acetamide; at 18 - 90 ℃; for 0.166667h; Product distribution / selectivity; Inert atmosphere;

upstream raw materials:

(1S)-1-(5-fluoropyrimidin-2-yl)ethanamine monohydrochloride

2-chloro-N-(1-methyl-1H-imidazol-4-yl)-7-[(4-methylphenyl)sulfonyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine

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