(2R,3R)-ethyl 2-[3-(4-chlorobenzyl)-2-oxoindolin-3-yl]-3,3,3-trifluoro-2-hydroxypropanoate

Base Information

Chemical Name:(2R,3R)-ethyl 2-[3-(4-chlorobenzyl)-2-oxoindolin-3-yl]-3,3,3-trifluoro-2-hydroxypropanoate
CAS No.:1003321-22-9
Molecular Formula:C₂₀H₁₇ClF₃NO₄
Molecular Weight:427.807
Hs Code.:

Synonyms:(2R,3R)-ethyl 2-[3-(4-chlorobenzyl)-2-oxoindolin-3-yl]-3,3,3-trifluoro-2-hydroxypropanoate

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Chemical Property of (2R,3R)-ethyl 2-[3-(4-chlorobenzyl)-2-oxoindolin-3-yl]-3,3,3-trifluoro-2-hydroxypropanoate

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Technology Process of (2R,3R)-ethyl 2-[3-(4-chlorobenzyl)-2-oxoindolin-3-yl]-3,3,3-trifluoro-2-hydroxypropanoate

There total 2 articles about (2R,3R)-ethyl 2-[3-(4-chlorobenzyl)-2-oxoindolin-3-yl]-3,3,3-trifluoro-2-hydroxypropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 131609-35-3
3-(4-chlorobenzyl)-1,3-dihydroindol-2-one

: 13081-18-0
ethyl-3,3,3-trifluoropyruvate

: ethyl 2-[3-(4-chlorobenzyl)-2-oxoindolin-3-yl]-3,3,3-trifluoro-2-hydroxypropanoate

: 1003321-22-9
(2R,3R)-ethyl 2-[3-(4-chlorobenzyl)-2-oxoindolin-3-yl]-3,3,3-trifluoro-2-hydroxypropanoate

: 1003321-11-6
(2S,3S)-ethyl 2-[3-(4-chlorobenzyl)-2-oxoindolin-3-yl]-3,3,3-trifluoro-2-hydroxypropanoate

Guidance literature:: quinine-1-naphthoate; In diethyl ether; at 0 - 20 ℃; for 16h; Title compound not separated from byproducts.;
DOI:10.1002/anie.200703317

Reference yield:

: 131609-35-3
3-(4-chlorobenzyl)-1,3-dihydroindol-2-one

: 13081-18-0
ethyl-3,3,3-trifluoropyruvate

: ethyl 2-[3-(4-chlorobenzyl)-2-oxoindolin-3-yl]-3,3,3-trifluoro-2-hydroxypropanoate

: 1003321-22-9
(2R,3R)-ethyl 2-[3-(4-chlorobenzyl)-2-oxoindolin-3-yl]-3,3,3-trifluoro-2-hydroxypropanoate

: ethyl 2-[3-(4-chlorobenzyl)-2-oxoindolin-3-yl]-3,3,3-trifluoro-2-hydroxypropanoate

Guidance literature:: 1,4-bis(9-O-dihydroquinidine)phthalazine; In diethyl ether; at 0 - 20 ℃; for 3h; Title compound not separated from byproducts.;
DOI:10.1002/anie.200703317