8-chloro-5-(N-methylamino)-1-[4-[(2-methylbenzoyl)amino]benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

Base Information

Chemical Name:8-chloro-5-(N-methylamino)-1-[4-[(2-methylbenzoyl)amino]benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine
CAS No.:154890-41-2
Molecular Formula:C₂₆H₂₆ClN₃O₂
Molecular Weight:447.964
Hs Code.:

Synonyms:8-chloro-5-(N-methylamino)-1-[4-[(2-methylbenzoyl)amino]benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 8-chloro-5-(N-methylamino)-1-[4-[(2-methylbenzoyl)amino]benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 8-chloro-5-(N-methylamino)-1-[4-[(2-methylbenzoyl)amino]benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

There total 12 articles about 8-chloro-5-(N-methylamino)-1-[4-[(2-methylbenzoyl)amino]benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-[4-(8-chloro-5-methylimino-2,3,4,5-tetrahydro-benzo[b]azepine-1-carbonyl)-phenyl]-2-methyl-benzamide

: 154890-41-2
8-chloro-5-(N-methylamino)-1-[4-[(2-methylbenzoyl)amino]benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

Guidance literature:: With sodium tetrahydroborate; In methanol; at 20 ℃;
DOI:10.1016/S0968-0896(99)00101-7

Reference yield:

: 5900-58-3
2-amino-4-chloro-benzoic acid methyl ester

: 154890-41-2
8-chloro-5-(N-methylamino)-1-[4-[(2-methylbenzoyl)amino]benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

Guidance literature:: Multi-step reaction with 9 steps

1.1: 95 percent / pyridine / 20 °C

2.1: 100 percent / K₂CO₃ / dimethylformamide / 4 h / 120 °C

3.1: t-BuOK / toluene / 0.5 h / Heating

3.2: 51 percent / conc. HCl / acetic acid / 5 h / Heating

4.1: 82 percent / polyphosphoric acid / 1.5 h / 80 - 100 °C

5.1: 95 percent / Et₃N / CH₂Cl₂ / 2 h / 20 °C

6.1: 51 percent / conc. HCl; H₂ / PtO₂ / acetic acid / 760 Torr

7.1: 100 percent / Et₃N / CH₂Cl₂ / 1.5 h / 20 °C

8.1: molecular sieves 4A / methanol / 6 h / Heating

9.1: 0.8 g / NaBH₄ / methanol / 20 °C

With pyridine; hydrogenchloride; sodium tetrahydroborate; PPA; 4 A molecular sieve; potassium tert-butylate; hydrogen; potassium carbonate; triethylamine; platinum(IV) oxide; In methanol; dichloromethane; acetic acid; N,N-dimethyl-formamide; toluene; 1.1: Tosylation / 2.1: Alkylation / 3.1: Cyclization / 3.2: Hydrolysis / 4.1: detosylation / 5.1: Acylation / 6.1: Hydrogenation / 7.1: Acylation / 8.1: Condensation / 9.1: Reduction;
DOI:10.1016/S0968-0896(99)00101-7

Reference yield:

: 38314-49-7
8-chloro-5-oxo-2,3,4,5-tetrahydro-1-p-toluenesulfonyl-1H-1-benzazepine

: 154890-41-2
8-chloro-5-(N-methylamino)-1-[4-[(2-methylbenzoyl)amino]benzoyl]-2,3,4,5-tetrahydro-1H-1-benzazepine

Guidance literature:: Multi-step reaction with 6 steps

1: 82 percent / polyphosphoric acid / 1.5 h / 80 - 100 °C

2: 95 percent / Et₃N / CH₂Cl₂ / 2 h / 20 °C

3: 51 percent / conc. HCl; H₂ / PtO₂ / acetic acid / 760 Torr

4: 100 percent / Et₃N / CH₂Cl₂ / 1.5 h / 20 °C

5: molecular sieves 4A / methanol / 6 h / Heating

6: 0.8 g / NaBH₄ / methanol / 20 °C

With hydrogenchloride; sodium tetrahydroborate; PPA; 4 A molecular sieve; hydrogen; triethylamine; platinum(IV) oxide; In methanol; dichloromethane; acetic acid; 1: detosylation / 2: Acylation / 3: Hydrogenation / 4: Acylation / 5: Condensation / 6: Reduction;
DOI:10.1016/S0968-0896(99)00101-7