4-Chloro-9h-fluoren-9-one

Base Information

• Chemical Name: 4-Chloro-9h-fluoren-9-one
• CAS No.: 4269-13-0
• Molecular Formula: C13H7ClO
• Molecular Weight: 214.651
• NSC Number: 90685
• DSSTox Substance ID: DTXSID60293557
• Nikkaji Number: J2.459.799G
• Wikidata: Q82032365
• Mol file: 4269-13-0.mol

Synonyms:4-chloro-9h-fluoren-9-one;4269-13-0;NSC90685;4-Chlorfluoren-9-on;NCIOpen2_005673;SCHEMBL8668864;DTXSID60293557;NSC-90685

Chemical Property of 4-Chloro-9h-fluoren-9-one

Chemical Property:

• Vapor Pressure: 7.34E-06mmHg at 25°C
• Boiling Point: 376.3°C at 760 mmHg
• Flash Point: 184.4°C
• Density: 1.369g/cm³
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 214.0185425
• Heavy Atom Count: 15
• Complexity: 276

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C3=C(C2=O)C=CC=C3Cl

Technology Process of 4-Chloro-9h-fluoren-9-one

There total 5 articles about 4-Chloro-9h-fluoren-9-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

1-Bromo-2-iodobenzene (583-55-1) + (S)-4-(tert-butyl)-2-(3-chlorophenyl)-4,5-dihydrooxazole → 4-chloro-9H-fluoren-9-one (4269-13-0) + (4S)-4-(tert-butyl)-2-(6-chloro-2'-iodo-(1,1'-biphenyl)-2-yl)-4,5-dihydrooxazole

Guidance literature:

(S)-4-(tert-butyl)-2-(3-chlorophenyl)-4,5-dihydrooxazole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h; Inert atmosphere;

1-Bromo-2-iodobenzene; In tetrahydrofuran; hexane; at -78 ℃; Inert atmosphere;

With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 25 ℃; for 12h; diastereoselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2016.01.047

Reference yield: 53.0%

1-Bromo-2-iodobenzene (583-55-1) + (S)-2-(3-chlorophenyl)-4-isopropyl-4,5-dihydrooxazole → 4-chloro-9H-fluoren-9-one (4269-13-0) + (4S)-2-(6-chloro-2'-iodo-(1,1'-biphenyl)-2-yl)-4-isopropyl-4,5-dihydrooxazole

Guidance literature:

(S)-2-(3-chlorophenyl)-4-isopropyl-4,5-dihydrooxazole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h; Inert atmosphere;

1-Bromo-2-iodobenzene; In tetrahydrofuran; hexane; at -78 ℃; Inert atmosphere;

With n-butyllithium; In tetrahydrofuran; hexane; at -78 - 25 ℃; for 12h; diastereoselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2016.01.047

Reference yield:

m-Chlorobenzoyl chloride (618-46-2) → 4-chloro-9H-fluoren-9-one (4269-13-0) + (4S)-2-(6-chloro-2'-iodo-(1,1'-biphenyl)-2-yl)-4-isopropyl-4,5-dihydrooxazole

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / dichloromethane / 8.5 h / 0 °C

2.1: thionyl chloride / dichloromethane / 25 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / -78 °C

3.2: 12 h / -78 °C

With n-butyllithium; thionyl chloride; triethylamine; In tetrahydrofuran; hexane; dichloromethane;

DOI:10.1002/ejoc.201501503

upstream raw materials:

1-Bromo-2-iodobenzene

m-Chlorobenzoyl chloride

3-chlorobenzoate