N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-methylbenzamide

Base Information

• Chemical Name: N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-methylbenzamide
• CAS No.: 2721-93-9
• Molecular Formula: C₁₉H₁₉N₃O₂
• Molecular Weight: 321.379
• Mol file: 2721-93-9.mol

Synonyms:N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-methylbenzamide

Chemical Property of N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-methylbenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-methylbenzamide

There total 2 articles about N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one (83-07-8) + 3-Methylbenzoyl chloride (1711-06-4) → N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-methylbenzamide (2721-93-9)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere;

DOI:10.1002/ejoc.202100513

Reference yield:

→ N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-methylbenzamide (2721-93-9)

Guidance literature:

aus 4-Aminoantipyrin und 3-Toluylsaeure in Gegenwart von PCl3 in Bzl.bei 3 Std.Δ auf 100grad(Bzl.);

Reference yield: 94.0%

para-bromotoluene (106-38-7) + N-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-methylbenzamide (2721-93-9) → 4,4'-dimethylbiphenyl-2-carboxylic acid (1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)amide

Guidance literature:

With tris(triphenylphosphine)ruthenium(II) chloride; sodium carbonate; In toluene; at 140 ℃; for 24h;

DOI:10.1002/ejoc.202100513

upstream raw materials:

4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one

3-Methylbenzoyl chloride