{6-[1-tert-butoxycarbonylamino-2-(1H-indol-3-yl)-ethyl]-3-oxo-1-phenylcarbamoyl-piperazin-2-yl}-acetic acid methyl ester

Base Information

• Chemical Name: {6-[1-tert-butoxycarbonylamino-2-(1H-indol-3-yl)-ethyl]-3-oxo-1-phenylcarbamoyl-piperazin-2-yl}-acetic acid methyl ester
• CAS No.: 477842-11-8
• Molecular Formula: C₂₉H₃₅N₅O₆
• Molecular Weight: 549.627

Synonyms:{6-[1-tert-butoxycarbonylamino-2-(1H-indol-3-yl)-ethyl]-3-oxo-1-phenylcarbamoyl-piperazin-2-yl}-acetic acid methyl ester

Chemical Property of {6-[1-tert-butoxycarbonylamino-2-(1H-indol-3-yl)-ethyl]-3-oxo-1-phenylcarbamoyl-piperazin-2-yl}-acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {6-[1-tert-butoxycarbonylamino-2-(1H-indol-3-yl)-ethyl]-3-oxo-1-phenylcarbamoyl-piperazin-2-yl}-acetic acid methyl ester

There total 2 articles about {6-[1-tert-butoxycarbonylamino-2-(1H-indol-3-yl)-ethyl]-3-oxo-1-phenylcarbamoyl-piperazin-2-yl}-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[2-tert-butoxycarbonylamino-1-cyano-3-(1H-indol-3-yl)-propylamino]-succinic acid dimethyl ester → {6-[1-tert-butoxycarbonylamino-2-(1H-indol-3-yl)-ethyl]-3-oxo-1-phenylcarbamoyl-piperazin-2-yl}-acetic acid methyl ester (477842-11-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 62 percent / hydrogen / Raney nickel / 20 °C

2: tetrahydrofuran / 24 h

With hydrogen; nickel; In tetrahydrofuran;

DOI:10.1016/S0040-4039(02)00964-4

Reference yield:

phenyl isocyanate (103-71-9) + {6-[1-tert-butoxycarbonylamino-2-(1H-indol-3-yl)-ethyl]-3-oxo-piperazin-2-yl}-acetic acid methyl ester (477842-10-7) → {6-[1-tert-butoxycarbonylamino-2-(1H-indol-3-yl)-ethyl]-3-oxo-1-phenylcarbamoyl-piperazin-2-yl}-acetic acid methyl ester (477842-11-8)

Guidance literature:

In tetrahydrofuran; for 24h;

DOI:10.1016/S0040-4039(02)00964-4

Reference yield: 90.0%

{6-[1-tert-butoxycarbonylamino-2-(1H-indol-3-yl)-ethyl]-3-oxo-1-phenylcarbamoyl-piperazin-2-yl}-acetic acid methyl ester (477842-11-8) → [2-(1H-indol-3-yl)-1-(1,6,8-trioxo-7-phenyl-octahydro-pyrazino[1,2-c]pyrimidin-4-yl)-ethyl]-carbamic acid tert-butyl ester (477842-13-0)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/S0040-4039(02)00964-4

upstream raw materials:

phenyl isocyanate

{6-[1-tert-butoxycarbonylamino-2-(1H-indol-3-yl)-ethyl]-3-oxo-piperazin-2-yl}-acetic acid methyl ester

Downstream raw materials:

[2-(1H-indol-3-yl)-1-(1,6,8-trioxo-7-phenyl-octahydro-pyrazino[1,2-c]pyrimidin-4-yl)-ethyl]-carbamic acid tert-butyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 477842-11-8 {6-[1-tert-butoxycarbonylamino-2-(1H-indol-3-yl)-ethyl]-3-oxo-1-phenylcarbamoyl-piperazin-2-yl}-acetic acid methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send