Technology Process of (2S)-1-benzyloxy-2-(tert-butoxycarbonyl)amino-4,4,4-trifluorobutane
There total 8 articles about (2S)-1-benzyloxy-2-(tert-butoxycarbonyl)amino-4,4,4-trifluorobutane which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride;
In
toluene;
at 80 ℃;
for 1h;
DOI:10.1021/jo0344384
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 88 percent / CuI / dimethylformamide; hexamethylphosphoric acid triamide / 10 h / 80 °C
2.1: AD-mix-α; methanesulfonamide / 2-methyl-propan-2-ol; H2O / 96 h / 20 °C
3.1: thionyl chloride; triethylamine / CH2Cl2 / 0.17 h / 0 °C
4.1: 0.92 g / NaIO4; RuCl3*3H2O / H2O; acetonitrile; CCl4 / 1 h / 20 °C
5.1: sodium azide / dimethylformamide / 4 h / 80 °C
5.2: 96 percent / sulfuric acid; water / tetrahydrofuran / 1 h
6.1: 92 percent / hydrogen / Pd/C / tetrahydrofuran / 10 h / 20 °C
7.1: 78 percent / DMAP; molecular sieves 4 Angstroem / toluene / 20 °C
8.1: 85 percent / Bu3SnH; AIBN / toluene / 1 h / 80 °C
With
dmap; ruthenium trichloride; sodium periodate; AD-mix-α; copper(l) iodide; thionyl chloride; sodium azide; 2,2'-azobis(isobutyronitrile); methanesulfonamide; 4 A molecular sieve; hydrogen; tri-n-butyl-tin hydride; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; tetrachloromethane; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; tert-butyl alcohol;
2.1: Sharpless asymmetric dihydroxylation;
DOI:10.1021/jo0344384
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: AD-mix-α; methanesulfonamide / 2-methyl-propan-2-ol; H2O / 96 h / 20 °C
2.1: thionyl chloride; triethylamine / CH2Cl2 / 0.17 h / 0 °C
3.1: 0.92 g / NaIO4; RuCl3*3H2O / H2O; acetonitrile; CCl4 / 1 h / 20 °C
4.1: sodium azide / dimethylformamide / 4 h / 80 °C
4.2: 96 percent / sulfuric acid; water / tetrahydrofuran / 1 h
5.1: 92 percent / hydrogen / Pd/C / tetrahydrofuran / 10 h / 20 °C
6.1: 78 percent / DMAP; molecular sieves 4 Angstroem / toluene / 20 °C
7.1: 85 percent / Bu3SnH; AIBN / toluene / 1 h / 80 °C
With
dmap; ruthenium trichloride; sodium periodate; AD-mix-α; thionyl chloride; sodium azide; 2,2'-azobis(isobutyronitrile); methanesulfonamide; 4 A molecular sieve; hydrogen; tri-n-butyl-tin hydride; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; tetrachloromethane; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile; tert-butyl alcohol;
1.1: Sharpless asymmetric dihydroxylation;
DOI:10.1021/jo0344384
