4-[4-(3-chloro-4-fluoro-phenyl)-thiazol-2-yl]-2'-nitro-biphenyl-2-carboxylic acid

Base Information

Chemical Name:4-[4-(3-chloro-4-fluoro-phenyl)-thiazol-2-yl]-2'-nitro-biphenyl-2-carboxylic acid
CAS No.:1428480-75-4
Molecular Formula:C₂₂H₁₂ClFN₂O₄S
Molecular Weight:454.866
Hs Code.:

Synonyms:4-[4-(3-chloro-4-fluoro-phenyl)-thiazol-2-yl]-2'-nitro-biphenyl-2-carboxylic acid

Suppliers and Price of 4-[4-(3-chloro-4-fluoro-phenyl)-thiazol-2-yl]-2'-nitro-biphenyl-2-carboxylic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-[4-(3-chloro-4-fluoro-phenyl)-thiazol-2-yl]-2'-nitro-biphenyl-2-carboxylic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-[4-(3-chloro-4-fluoro-phenyl)-thiazol-2-yl]-2'-nitro-biphenyl-2-carboxylic acid

There total 6 articles about 4-[4-(3-chloro-4-fluoro-phenyl)-thiazol-2-yl]-2'-nitro-biphenyl-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1428482-20-5
4-[4-(3-chloro-4-fluoro-phenyl)-thiazol-2-yl]-2'-nitro-biphenyl-2-carboxylic acid methyl ester

: 1428480-75-4
4-[4-(3-chloro-4-fluoro-phenyl)-thiazol-2-yl]-2'-nitro-biphenyl-2-carboxylic acid

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; water; at 50 ℃; for 4h;

Reference yield:

: 1428482-13-6
2'-nitro-4-thiocarbamoyl-biphenyl-2-carboxylic acid methyl ester

: 1428480-75-4
4-[4-(3-chloro-4-fluoro-phenyl)-thiazol-2-yl]-2'-nitro-biphenyl-2-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 20 h / 40 °C

2: sodium hydroxide / water; 1,4-dioxane / 4 h / 50 °C

With sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 52727-57-8
5-bromo-2-aminobenzoic acid methyl ester

: 1428480-75-4
4-[4-(3-chloro-4-fluoro-phenyl)-thiazol-2-yl]-2'-nitro-biphenyl-2-carboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 1-methyl-pyrrolidin-2-one / 4 h / 180 °C

2: tert.-butylnitrite; copper(ll) bromide / acetonitrile / 20 h / 0 - 20 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate / water; 1,4-dioxane / 3.5 h / Reflux

4: O,O-Diethyl hydrogen phosphorodithioate; water / tetrahydrofuran / 45 h / 80 °C

5: tetrahydrofuran / 20 h / 40 °C

6: sodium hydroxide / water; 1,4-dioxane / 4 h / 50 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tert.-butylnitrite; water; potassium carbonate; O,O-Diethyl hydrogen phosphorodithioate; sodium hydroxide; copper(ll) bromide; In tetrahydrofuran; 1,4-dioxane; 1-methyl-pyrrolidin-2-one; water; acetonitrile;