3-{4-[(2E)-3-(dimethylamino)prop-2-enoyl]phenoxy}-5-[(1S)-2-methoxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide

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Chemical Name:3-{4-[(2E)-3-(dimethylamino)prop-2-enoyl]phenoxy}-5-[(1S)-2-methoxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide
CAS No.:871657-83-9
Molecular Formula:C₂₆H₃₀N₄O₅
Molecular Weight:478.548
Hs Code.:

Synonyms:3-{4-[(2E)-3-(dimethylamino)prop-2-enoyl]phenoxy}-5-[(1S)-2-methoxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide

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Chemical Property of 3-{4-[(2E)-3-(dimethylamino)prop-2-enoyl]phenoxy}-5-[(1S)-2-methoxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide

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Technology Process of 3-{4-[(2E)-3-(dimethylamino)prop-2-enoyl]phenoxy}-5-[(1S)-2-methoxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide

There total 8 articles about 3-{4-[(2E)-3-(dimethylamino)prop-2-enoyl]phenoxy}-5-[(1S)-2-methoxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 871657-84-0
3-(4-acetylphenoxy)-5-[(1S)-2-methoxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 871657-83-9
3-{4-[(2E)-3-(dimethylamino)prop-2-enoyl]phenoxy}-5-[(1S)-2-methoxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide

Guidance literature:: at 100 ℃; for 2.33333h; Microwave;

Reference yield:

: 851885-41-1
3-{[(1S)-1-methyl-2-(methyloxy)ethyl]oxy}-5-[(phenylmethyl)oxy]benzoic acid

: 871657-83-9
3-{4-[(2E)-3-(dimethylamino)prop-2-enoyl]phenoxy}-5-[(1S)-2-methoxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 2 - 16 h / 0 - 20 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C

3: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 70 h

4: C₁₃H₃₀N₄PPol; Potassium benzoate / 1-methyl-pyrrolidin-2-one / 1 h / 200 °C / Microwave

5: 2.33 h / 100 °C / Microwave

With oxalyl dichloride; C₁₃H₃₀N₄PPol; hydrogen; Potassium benzoate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; N,N-dimethyl-formamide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane;

Reference yield:

: C₁₈H₁₉ClO₄

: 871657-83-9
3-{4-[(2E)-3-(dimethylamino)prop-2-enoyl]phenoxy}-5-[(1S)-2-methoxy-1-methylethoxy]-N-(1-methyl-1H-pyrazol-3-yl)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C

2: hydrogen / palladium 10% on activated carbon / tetrahydrofuran; methanol / 70 h

3: C₁₃H₃₀N₄PPol; Potassium benzoate / 1-methyl-pyrrolidin-2-one / 1 h / 200 °C / Microwave

4: 2.33 h / 100 °C / Microwave

With C₁₃H₃₀N₄PPol; hydrogen; Potassium benzoate; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane;