Technology Process of 3-benzyl-2,3,4,5-tetrahydro-1H-benzo[c]azepine
There total 12 articles about 3-benzyl-2,3,4,5-tetrahydro-1H-benzo[c]azepine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
tetrahydrofuran;
at 20 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 12 steps
1.1: n-butyllithium / tetrahydrofuran / 0.33 h / -78 °C
1.2: 0.83 h / -78 °C
2.1: sodium carbonate / dichloromethane; methanol / 20 °C
3.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 2 h / 20 °C / Inert atmosphere
4.1: hydrogen; palladium 10% on activated carbon / methanol / 760.05 Torr
5.1: triethylamine / 0 - 20 °C
6.1: 15-crown-5; sodium azide / N,N-dimethyl-formamide / 24 h / 85 °C / Inert atmosphere
7.1: hydrogen; palladium 10% on activated carbon / methanol / 760.05 Torr
8.1: triethylamine / dichloromethane / 0 - 20 °C
9.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
10.1: N-Bromosuccinimide; triphenylphosphine / dichloromethane / 20 °C
11.1: dichloromethane / 20 °C
12.1: potassium carbonate / tetrahydrofuran / 3 h / 20 °C
With
bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; copper(l) iodide; lithium aluminium tetrahydride; n-butyllithium; sodium azide; 15-crown-5; palladium 10% on activated carbon; hydrogen; sodium carbonate; potassium carbonate; triethylamine; triphenylphosphine;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 11 steps
1: sodium carbonate / dichloromethane; methanol / 20 °C
2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 2 h / 20 °C / Inert atmosphere
3: hydrogen; palladium 10% on activated carbon / methanol / 760.05 Torr
4: triethylamine / 0 - 20 °C
5: 15-crown-5; sodium azide / N,N-dimethyl-formamide / 24 h / 85 °C / Inert atmosphere
6: hydrogen; palladium 10% on activated carbon / methanol / 760.05 Torr
7: triethylamine / dichloromethane / 0 - 20 °C
8: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
9: N-Bromosuccinimide; triphenylphosphine / dichloromethane / 20 °C
10: dichloromethane / 20 °C
11: potassium carbonate / tetrahydrofuran / 3 h / 20 °C
With
bis-triphenylphosphine-palladium(II) chloride; N-Bromosuccinimide; copper(l) iodide; lithium aluminium tetrahydride; sodium azide; 15-crown-5; palladium 10% on activated carbon; hydrogen; sodium carbonate; potassium carbonate; triethylamine; triphenylphosphine;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
