N-(1-methylethyl)-2-[3-[3-(methyloxy)phenyl]-1-oxo-7-{[3-(1-piperidinyl)-propyl]oxy}pyrrolo[1,2-a]pyrazin-2(1H)-yl]acetamide

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Chemical Name:N-(1-methylethyl)-2-[3-[3-(methyloxy)phenyl]-1-oxo-7-{[3-(1-piperidinyl)-propyl]oxy}pyrrolo[1,2-a]pyrazin-2(1H)-yl]acetamide
CAS No.:1192683-10-5
Molecular Formula:C₂₇H₃₆N₄O₄
Molecular Weight:480.607
Hs Code.:

Synonyms:N-(1-methylethyl)-2-[3-[3-(methyloxy)phenyl]-1-oxo-7-{[3-(1-piperidinyl)-propyl]oxy}pyrrolo[1,2-a]pyrazin-2(1H)-yl]acetamide

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Chemical Property of N-(1-methylethyl)-2-[3-[3-(methyloxy)phenyl]-1-oxo-7-{[3-(1-piperidinyl)-propyl]oxy}pyrrolo[1,2-a]pyrazin-2(1H)-yl]acetamide

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Technology Process of N-(1-methylethyl)-2-[3-[3-(methyloxy)phenyl]-1-oxo-7-{[3-(1-piperidinyl)-propyl]oxy}pyrrolo[1,2-a]pyrazin-2(1H)-yl]acetamide

There total 7 articles about N-(1-methylethyl)-2-[3-[3-(methyloxy)phenyl]-1-oxo-7-{[3-(1-piperidinyl)-propyl]oxy}pyrrolo[1,2-a]pyrazin-2(1H)-yl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2895-21-8
2-chloro-N-isopropylacetamide

: 1192686-31-9
3-(3-methoxyphenyl)-7-(3-(piperidin-1-yl)propoxy)pyrrolo[1,2-a]pyrazin-1(2H)-one

: 1192683-10-5
N-(1-methylethyl)-2-[3-[3-(methyloxy)phenyl]-1-oxo-7-{[3-(1-piperidinyl)-propyl]oxy}pyrrolo[1,2-a]pyrazin-2(1H)-yl]acetamide

Guidance literature:: With tetrabutylammomium bromide; sodium iodide; potassium hydroxide; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

Reference yield:

: 110-89-4
piperidine

: C₂₃H₂₉N₃O₇S

: 1192683-10-5
N-(1-methylethyl)-2-[3-[3-(methyloxy)phenyl]-1-oxo-7-{[3-(1-piperidinyl)-propyl]oxy}pyrrolo[1,2-a]pyrazin-2(1H)-yl]acetamide

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 65 ℃; for 9h; Inert atmosphere;
DOI:10.1016/j.bmcl.2010.07.037

Reference yield:

: 1192686-28-4
methyl 1-(2-(3-methoxyphenyl)-2-oxoethyl)-4-(3-(piperidin-1-yl)propoxy)-1H-pyrrole-2-carboxylate

: 1192683-10-5
N-(1-methylethyl)-2-[3-[3-(methyloxy)phenyl]-1-oxo-7-{[3-(1-piperidinyl)-propyl]oxy}pyrrolo[1,2-a]pyrazin-2(1H)-yl]acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium acetate; acetic acid / 16 h / Reflux

2: tetrabutylammomium bromide; sodium iodide; potassium hydroxide / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With ammonium acetate; tetrabutylammomium bromide; acetic acid; sodium iodide; potassium hydroxide; In tetrahydrofuran;