[1-((2R,4S,5R)-4-Hydroxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-acetonitrile

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Chemical Name:[1-((2R,4S,5R)-4-Hydroxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-acetonitrile
CAS No.:308832-11-3
Molecular Formula:C₃₀H₂₇N₃O₅
Molecular Weight:509.561
Hs Code.:
Mol file:308832-11-3.mol

Synonyms:[1-((2R,4S,5R)-4-Hydroxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-acetonitrile

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Chemical Property of [1-((2R,4S,5R)-4-Hydroxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-acetonitrile Edit

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Technology Process of [1-((2R,4S,5R)-4-Hydroxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-acetonitrile

There total 3 articles about [1-((2R,4S,5R)-4-Hydroxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58589-18-7
3',5'-di-O-acetyl-5-bromomethyl-2'-deoxyuridine

: 308832-11-3
[1-((2R,4S,5R)-4-Hydroxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-acetonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 1.17 g / dimethylformamide / 10 h / 90 °C

2: 72 percent / NH₃ / methanol

With ammonia; In methanol; N,N-dimethyl-formamide; 1: Substitution / 2: Deacetylation / 3: tritylation;
DOI:10.1080/00397910008086944

Reference yield:

: 308832-06-6
5-(cyanomethyl)-3',5'-di-O-acetyl-2'-deoxyuridine

: 308832-11-3
[1-((2R,4S,5R)-4-Hydroxy-5-trityloxymethyl-tetrahydro-furan-2-yl)-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl]-acetonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / NH₃ / methanol

With ammonia; In methanol; 1: Deacetylation / 2: tritylation;
DOI:10.1080/00397910008086944