4-amino-5-benzoyl-isoxazole-3-carboxylic acid (4-chlorobenzylidene)-hydrazide

Base Information

• Chemical Name: 4-amino-5-benzoyl-isoxazole-3-carboxylic acid (4-chlorobenzylidene)-hydrazide
• CAS No.: 1236197-24-2
• Molecular Formula: C₁₈H₁₃ClN₄O₃
• Molecular Weight: 368.779
• Mol file: 1236197-24-2.mol

Synonyms:4-amino-5-benzoyl-isoxazole-3-carboxylic acid (4-chlorobenzylidene)-hydrazide

Chemical Property of 4-amino-5-benzoyl-isoxazole-3-carboxylic acid (4-chlorobenzylidene)-hydrazide

Chemical Property:

Purity/Quality:

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Technology Process of 4-amino-5-benzoyl-isoxazole-3-carboxylic acid (4-chlorobenzylidene)-hydrazide

There total 1 articles about 4-amino-5-benzoyl-isoxazole-3-carboxylic acid (4-chlorobenzylidene)-hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.3%

4-amino-5-benzoylisoxazole-3-carbohydrazide (1093747-66-0) + 4-chlorobenzaldehyde (104-88-1) → 4-amino-5-benzoyl-isoxazole-3-carboxylic acid (4-chlorobenzylidene)-hydrazide (1236197-24-2)

Guidance literature:

In 1,4-dioxane; at 80 ℃; for 5h;

DOI:10.1002/jhet.373

Reference yield: 59.4%

4-amino-5-benzoyl-isoxazole-3-carboxylic acid (4-chlorobenzylidene)-hydrazide (1236197-24-2) + orthoformic acid triethyl ester (122-51-0) → 3-benzoyl-6-[(4-chloro-benzylidene)-amino]-6H-isoxazolo[4,3-d]pyrimidin-7-one (1236197-27-5)

Guidance literature:

4-amino-5-benzoyl-isoxazole-3-carboxylic acid (4-chlorobenzylidene)-hydrazide; orthoformic acid triethyl ester; With acetic anhydride; for 5h; Reflux;

With ammonia; In ethanol; at 20 ℃; for 1h;

DOI:10.1002/jhet.373

upstream raw materials:

4-amino-5-benzoylisoxazole-3-carbohydrazide

4-chlorobenzaldehyde

Downstream raw materials:

3-benzoyl-6-[(4-chloro-benzylidene)-amino]-6H-isoxazolo[4,3-d]pyrimidin-7-one