allyl (6S,7S)-8-oxo-7-(tritylamino)-1-aza-4-oxabicyclo<4.2.0>oct-2-ene-2-carboxylate

Base Information

Chemical Name:allyl (6S,7S)-8-oxo-7-(tritylamino)-1-aza-4-oxabicyclo<4.2.0>oct-2-ene-2-carboxylate
CAS No.:113599-80-7
Molecular Formula:C₂₉H₂₆N₂O₄
Molecular Weight:466.536
Hs Code.:

Synonyms:allyl (6S,7S)-8-oxo-7-(tritylamino)-1-aza-4-oxabicyclo<4.2.0>oct-2-ene-2-carboxylate

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Chemical Property of allyl (6S,7S)-8-oxo-7-(tritylamino)-1-aza-4-oxabicyclo<4.2.0>oct-2-ene-2-carboxylate

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Technology Process of allyl (6S,7S)-8-oxo-7-(tritylamino)-1-aza-4-oxabicyclo<4.2.0>oct-2-ene-2-carboxylate

There total 6 articles about allyl (6S,7S)-8-oxo-7-(tritylamino)-1-aza-4-oxabicyclo<4.2.0>oct-2-ene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 113599-73-8
allyl 2-<(3S,4S)-4-(hydroxymethyl)-2-oxo-3-tritylamino-1-azetidinyl>-3-oxopropanoate

: 113599-80-7
allyl (6S,7S)-8-oxo-7-(tritylamino)-1-aza-4-oxabicyclo<4.2.0>oct-2-ene-2-carboxylate

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran;
DOI:10.1021/jm00401a020

Reference yield:

: 40630-84-0
allyl bromoacetate

: 113599-80-7
allyl (6S,7S)-8-oxo-7-(tritylamino)-1-aza-4-oxabicyclo<4.2.0>oct-2-ene-2-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: 59 percent / tetrabutylammonium bromide, KOH / tetrahydrofuran / 20 h

2: 86 percent / lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C

3: 89 percent / tetrabutylammonium fluoride / tetrahydrofuran

4: 39 percent / Ph₃P, diisopropyl azodicarboxylate / tetrahydrofuran

With potassium hydroxide; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1021/jm00401a020

Reference yield:

: 76-83-5
trityl chloride

: 113599-80-7
allyl (6S,7S)-8-oxo-7-(tritylamino)-1-aza-4-oxabicyclo<4.2.0>oct-2-ene-2-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: NEt₃ / CH₂Cl₂ / 1.5 h

2: 59 percent / tetrabutylammonium bromide, KOH / tetrahydrofuran / 20 h

3: 86 percent / lithium bis(trimethylsilyl)amide / tetrahydrofuran / -78 °C

4: 89 percent / tetrabutylammonium fluoride / tetrahydrofuran

5: 39 percent / Ph₃P, diisopropyl azodicarboxylate / tetrahydrofuran

With potassium hydroxide; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; tetrabutylammomium bromide; triethylamine; triphenylphosphine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00401a020