(E)-8-[(3aS,5S,6aR)-2-Hydroxy-5-(tetrahydro-pyran-2-yloxy)-hexahydro-cyclopenta[b]furan-4-yl]-6-(tetrahydro-pyran-2-yloxy)-oct-7-enoic acid 1-(3-chloro-phenyl)-1-methyl-ethyl ester

Base Information

Chemical Name:(E)-8-[(3aS,5S,6aR)-2-Hydroxy-5-(tetrahydro-pyran-2-yloxy)-hexahydro-cyclopenta[b]furan-4-yl]-6-(tetrahydro-pyran-2-yloxy)-oct-7-enoic acid 1-(3-chloro-phenyl)-1-methyl-ethyl ester
CAS No.:81266-83-3
Molecular Formula:C₃₄H₄₉ClO₈
Molecular Weight:621.211
Hs Code.:

(E)-8-[(3aS,5S,6aR)-2-Hydroxy-5-(tetrahydro-pyran-2-yloxy)-hexahydro-cyclopenta[b]furan-4-yl]-6-(tetrahydro-pyran-2-yloxy)-oct-7-enoic acid 1-(3-chloro-phenyl)-1-methyl-ethyl ester

Synonyms:(E)-8-[(3aS,5S,6aR)-2-Hydroxy-5-(tetrahydro-pyran-2-yloxy)-hexahydro-cyclopenta[b]furan-4-yl]-6-(tetrahydro-pyran-2-yloxy)-oct-7-enoic acid 1-(3-chloro-phenyl)-1-methyl-ethyl ester

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Chemical Property of (E)-8-[(3aS,5S,6aR)-2-Hydroxy-5-(tetrahydro-pyran-2-yloxy)-hexahydro-cyclopenta[b]furan-4-yl]-6-(tetrahydro-pyran-2-yloxy)-oct-7-enoic acid 1-(3-chloro-phenyl)-1-methyl-ethyl ester

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Technology Process of (E)-8-[(3aS,5S,6aR)-2-Hydroxy-5-(tetrahydro-pyran-2-yloxy)-hexahydro-cyclopenta[b]furan-4-yl]-6-(tetrahydro-pyran-2-yloxy)-oct-7-enoic acid 1-(3-chloro-phenyl)-1-methyl-ethyl ester

There total 7 articles about (E)-8-[(3aS,5S,6aR)-2-Hydroxy-5-(tetrahydro-pyran-2-yloxy)-hexahydro-cyclopenta[b]furan-4-yl]-6-(tetrahydro-pyran-2-yloxy)-oct-7-enoic acid 1-(3-chloro-phenyl)-1-methyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 81266-81-1,81338-90-1
6-(-Tetrahydropyranyloxy)-8-<3-oxo-7-(2-terahydropyranyloxy)-2-oxa-6-bicyclo<3.3.0>octyl>-7-octensaeure-1-m-chlorphenyl-1-methylethylester

: 81266-83-3
(E)-8-[(3aS,5S,6aR)-2-Hydroxy-5-(tetrahydro-pyran-2-yloxy)-hexahydro-cyclopenta[b]furan-4-yl]-6-(tetrahydro-pyran-2-yloxy)-oct-7-enoic acid 1-(3-chloro-phenyl)-1-methyl-ethyl ester

Guidance literature:: With sodium bis(2-methoxyethoxy)aluminium dihydride; In toluene; at -70 ℃; for 6h;
DOI:10.1002/jlac.198219820116

Reference yield:

: 81266-68-4
Hexanedioic acid 1-(3-chloro-phenyl)-1-methyl-ethyl ester methyl ester

: 81266-83-3
(E)-8-[(3aS,5S,6aR)-2-Hydroxy-5-(tetrahydro-pyran-2-yloxy)-hexahydro-cyclopenta[b]furan-4-yl]-6-(tetrahydro-pyran-2-yloxy)-oct-7-enoic acid 1-(3-chloro-phenyl)-1-methyl-ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1) 1,6 M butyllithium / 1) THF, hexane, -78 deg C, 2) -78 deg C, 7h; 20 deg C, 2h

2: 1) NaH, LiCl / 1) THF, hexane, 2) 1,2-dimethoxyethane, 1h, 25 deg C

3: 95 percent / ZnCl₂, NaBH₄, / 1,2-dimethoxy-ethane / 1) 1,5 h, -20 deg C, 2) 1,5 h, 0 deg C, 3) 1,5 h, 20 deg C

4: 69 percent / K₂CO₃ / ethanol / 1.5 h / 25 °C

5: 85 percent / 2percent 4-toluoene sulfonic acid / CH₂Cl₂; tetrahydrofuran / 2 h / 20 °C

6: 100 percent / 70percent Na-dihydridobis(2-methoxyethoxy)aluminat / toluene / 6 h / -70 °C

With sodium tetrahydroborate; n-butyllithium; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; sodium bis(2-methoxyethoxy)aluminium dihydride; lithium chloride; zinc(II) chloride; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; toluene;
DOI:10.1002/jlac.198219820116

Reference yield:

: 38754-71-1,39265-58-2,39648-29-8,40667-54-7,42586-63-0,51642-99-0,52522-09-5
Biphenyl-4-carboxylic acid (3aS,5S,6aR)-4-formyl-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester

: 81266-83-3
(E)-8-[(3aS,5S,6aR)-2-Hydroxy-5-(tetrahydro-pyran-2-yloxy)-hexahydro-cyclopenta[b]furan-4-yl]-6-(tetrahydro-pyran-2-yloxy)-oct-7-enoic acid 1-(3-chloro-phenyl)-1-methyl-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1) NaH, LiCl / 1) THF, hexane, 2) 1,2-dimethoxyethane, 1h, 25 deg C

2: 95 percent / ZnCl₂, NaBH₄, / 1,2-dimethoxy-ethane / 1) 1,5 h, -20 deg C, 2) 1,5 h, 0 deg C, 3) 1,5 h, 20 deg C

3: 69 percent / K₂CO₃ / ethanol / 1.5 h / 25 °C

4: 85 percent / 2percent 4-toluoene sulfonic acid / CH₂Cl₂; tetrahydrofuran / 2 h / 20 °C

5: 100 percent / 70percent Na-dihydridobis(2-methoxyethoxy)aluminat / toluene / 6 h / -70 °C

With sodium tetrahydroborate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; sodium bis(2-methoxyethoxy)aluminium dihydride; lithium chloride; zinc(II) chloride; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; toluene;
DOI:10.1002/jlac.198219820116