N¹-(2-ammonioethyl)-2,3-dihydrobenzamide

Base Information

• Chemical Name: N¹-(2-ammonioethyl)-2,3-dihydrobenzamide
• CAS No.: 153801-67-3
• Molecular Formula: C₉H₁₂N₂O₃
• Molecular Weight: 196.206
• Mol file: 153801-67-3.mol

Synonyms:N¹-(2-ammonioethyl)-2,3-dihydrobenzamide

Chemical Property of N¹-(2-ammonioethyl)-2,3-dihydrobenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N¹-(2-ammonioethyl)-2,3-dihydrobenzamide

There total 4 articles about N¹-(2-ammonioethyl)-2,3-dihydrobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-(2-aminoethyl)-2,3-bis(benzyloxy)benzamide → N1-(2-ammonioethyl)-2,3-dihydrobenzamide (153801-67-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol; for 4h;

DOI:10.1080/00958972.2017.1340644

Reference yield:

tert-butyl N-{2-[(2,3-dihydroxybenzoyl)amino]ethyl}carbamate (478167-93-0) → N1-(2-ammonioethyl)-2,3-dihydrobenzamide (153801-67-3)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1248/cpb.50.578

Reference yield:

2,3-Dihydroxybenzoic acid (303-38-8) → N1-(2-ammonioethyl)-2,3-dihydrobenzamide (153801-67-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / 1,3-dicyclohexylcarbodiimide / tetrahydrofuran / 18 h / 20 °C

2: trifluoroacetic acid / CH₂Cl₂ / 16 h / 20 °C

With dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1248/cpb.50.578

upstream raw materials:

tert-butyl N-{2-[(2,3-dihydroxybenzoyl)amino]ethyl}carbamate

2,3-Dihydroxybenzoic acid